Prolonged exercise reduces Ca2+ release in rat skeletal muscle sarcoplasmic reticulum

Terence G. Favero, Isaac N Pessah, Gary A. Klug

Research output: Contribution to journalArticlepeer-review

62 Scopus citations


Prolonged exercise decreased the rate of Ca+ release in sarcoplasmic reticulum (SR) vesicles isolated from rat muscle by 20-30% when release was initiated by 5, 10, and 20 μM AgNO3. [3H]Ryanodine binding was also depressed by 20% in SR vesicles isolated from the exercised animals. In contrast, the maximum amount of Ca2+ released by Ag+ remained unaffected by exercise. The passive permeability of SR vesicles and the rate of Ca2+ release in the presence of ruthenium red, a known inhibitor of the Ca2+ release mechanism, was not affected by prolonged exercise. These results suggest that exercise depressed Ca2+ release from SR by directly modifying the Ca2+ release channel.

Original languageEnglish (US)
Pages (from-to)472-475
Number of pages4
JournalPflügers Archiv European Journal of Physiology
Issue number5
StatePublished - Feb 1993


  • Ca release
  • Exercise
  • Sarcoplasmic reticulum

ASJC Scopus subject areas

  • Physiology


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