Prolonged Exercise Augments Plasma Triglyceride Clearance

Stanley P. Sady, Paul D. Thompson, Eileen M. Cullinane, Mark A. Kantor, Evelyn Domagala, Peter N. Herbert

Research output: Contribution to journalArticle

91 Scopus citations

Abstract

We studied ten male distance runners before and after a marathon to determine the effects of prolonged exercise on serum lipoprotein values and the capacity to clear plasma triglycerides. Serum lipid and lipoprotein concentrations, intravenous fat clearance, and postheparin plasma lipolytic activities were measured 24 hours before and 18 hours after the race. The clearance rate of exogenous fat increased 76% ±64% postheparin lipoprotein lipase activity increased 46% ±35% and fasting triglyceride levels decreased 26% ±13% after the race. High-density lipoprotein (HDL) cholesterol level increased 10%±8% primarily due to a 19%± 17% increase in the HDL 2 subfraction. Changes in the clearance rate of exogenous fat were directly related to changes in HDL cholesterol level and the HDL2 subfraction. Thus, the rise in HDL cholesterol concentrations after prolonged exercise may be a consequence of enhanced fat clearance.

Original languageEnglish (US)
Pages (from-to)2552-2555
Number of pages4
JournalJAMA - Journal of the American Medical Association
Volume256
Issue number18
DOIs
StatePublished - Nov 14 1986
Externally publishedYes

ASJC Scopus subject areas

  • Medicine(all)

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    Sady, S. P., Thompson, P. D., Cullinane, E. M., Kantor, M. A., Domagala, E., & Herbert, P. N. (1986). Prolonged Exercise Augments Plasma Triglyceride Clearance. JAMA - Journal of the American Medical Association, 256(18), 2552-2555. https://doi.org/10.1001/jama.1986.03380180114030