Prolongation of the corrected QT complex - A cause of sudden cardiac death in the mountain environment?

J. S. Windsor, George W Rodway, R. Mukherjee, P. G. Firth, M. Shattock, H. E. Montgomery

Research output: Contribution to journalArticle

2 Citations (Scopus)

Abstract

In the mountain environment sudden cardiac death (SCD) has been shown to be responsible for the deaths of up to 52% of downhill skiers and 30% of hikers. The majority of SCD's are precipitated by a ventricular arrhythmia. Although most are likely to result from structural abnormalities associated with conditions such as ischaemic heart disease, a small but signifcant number may be due to abnormalities in ion channel activity, commonly known as, "channelopathies". Channelopathies have the potential to lengthen the time between ventricular depolarisation and repolarisation that can result in prolongation of the corrected QT interval (QTc) and episodes of polymorphic ventricular tachycardia (PVT) and eventually, ventricular fibrillation. This review examines the factors that prolong the QTc interval in the mountain environment and outlines a practical framework for preventing the life threatening arrhythmias that are associated with this condition.

Original languageEnglish (US)
Pages (from-to)63-67
Number of pages5
JournalJournal of the Royal Army Medical Corps
Volume157
Issue number1
StatePublished - 2011
Externally publishedYes

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Channelopathies
Sudden Cardiac Death
Cardiac Arrhythmias
Ventricular Fibrillation
Ventricular Tachycardia
Ion Channels
Myocardial Ischemia

ASJC Scopus subject areas

  • Medicine(all)

Cite this

Windsor, J. S., Rodway, G. W., Mukherjee, R., Firth, P. G., Shattock, M., & Montgomery, H. E. (2011). Prolongation of the corrected QT complex - A cause of sudden cardiac death in the mountain environment? Journal of the Royal Army Medical Corps, 157(1), 63-67.

Prolongation of the corrected QT complex - A cause of sudden cardiac death in the mountain environment? / Windsor, J. S.; Rodway, George W; Mukherjee, R.; Firth, P. G.; Shattock, M.; Montgomery, H. E.

In: Journal of the Royal Army Medical Corps, Vol. 157, No. 1, 2011, p. 63-67.

Research output: Contribution to journalArticle

Windsor, JS, Rodway, GW, Mukherjee, R, Firth, PG, Shattock, M & Montgomery, HE 2011, 'Prolongation of the corrected QT complex - A cause of sudden cardiac death in the mountain environment?', Journal of the Royal Army Medical Corps, vol. 157, no. 1, pp. 63-67.
Windsor, J. S. ; Rodway, George W ; Mukherjee, R. ; Firth, P. G. ; Shattock, M. ; Montgomery, H. E. / Prolongation of the corrected QT complex - A cause of sudden cardiac death in the mountain environment?. In: Journal of the Royal Army Medical Corps. 2011 ; Vol. 157, No. 1. pp. 63-67.
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