Proliferative and nonproliferative lesions of the rat and mouse mammary, Zymbal's, preputial, and clitoral glands.

Daniel Rudmann, Robert Cardiff, Luc Chouinard, Dawn Goodman, Karin Küttler, Heike Marxfeld, Alfredo Molinolo, Silke Treumann, Katsuhiko Yoshizawa, Mammary, Zymbal's, Preputial, INHAND Mammary, Zymbal's, Preputial,

Research output: Contribution to journalArticle

41 Citations (Scopus)

Abstract

The mammary gland of laboratory rodents is an important organ for the evaluation of effects of xenobiotics, especially those that perturb hormonal homeostasis or are potentially carcinogenic. Mammary gland cancer is a leading cause of human mortality and morbidity worldwide and is a subject of major research efforts utilizing rodent models. Zymbal's, preputial, and clitoral glands are standard tissues that are evaluated in animal models that enable human risk assessment of xenobiotics. A widely accepted and utilized international harmonization of nomenclature for mammary, Zymbal's, preputial, and clitoral gland lesions in laboratory animals will improve diagnostic alignment among regulatory and scientific research organizations and enrich international exchanges of information among toxicologists and pathologists.

Original languageEnglish (US)
JournalToxicologic Pathology
Volume40
Issue number6 Suppl
StatePublished - Aug 1 2012
Externally publishedYes

Fingerprint

Xenobiotics
Human Mammary Glands
Rats
Rodentia
Animals
Breast
Laboratory Animals
Terminology
Research
Risk assessment
Homeostasis
Animal Models
Organizations
Tissue
Breast Neoplasms
Morbidity
Mortality
Pathologists

ASJC Scopus subject areas

  • Pathology and Forensic Medicine
  • Toxicology
  • Cell Biology
  • Molecular Biology

Cite this

Rudmann, D., Cardiff, R., Chouinard, L., Goodman, D., Küttler, K., Marxfeld, H., ... INHAND Mammary, Zymbal's, Preputial, M. Z. P. (2012). Proliferative and nonproliferative lesions of the rat and mouse mammary, Zymbal's, preputial, and clitoral glands. Toxicologic Pathology, 40(6 Suppl).

Proliferative and nonproliferative lesions of the rat and mouse mammary, Zymbal's, preputial, and clitoral glands. / Rudmann, Daniel; Cardiff, Robert; Chouinard, Luc; Goodman, Dawn; Küttler, Karin; Marxfeld, Heike; Molinolo, Alfredo; Treumann, Silke; Yoshizawa, Katsuhiko; INHAND Mammary, Zymbal's, Preputial, Mammary, Zymbal's, Preputial,.

In: Toxicologic Pathology, Vol. 40, No. 6 Suppl, 01.08.2012.

Research output: Contribution to journalArticle

Rudmann, D, Cardiff, R, Chouinard, L, Goodman, D, Küttler, K, Marxfeld, H, Molinolo, A, Treumann, S, Yoshizawa, K & INHAND Mammary, Zymbal's, Preputial, MZP 2012, 'Proliferative and nonproliferative lesions of the rat and mouse mammary, Zymbal's, preputial, and clitoral glands.', Toxicologic Pathology, vol. 40, no. 6 Suppl.
Rudmann, Daniel ; Cardiff, Robert ; Chouinard, Luc ; Goodman, Dawn ; Küttler, Karin ; Marxfeld, Heike ; Molinolo, Alfredo ; Treumann, Silke ; Yoshizawa, Katsuhiko ; INHAND Mammary, Zymbal's, Preputial, Mammary, Zymbal's, Preputial,. / Proliferative and nonproliferative lesions of the rat and mouse mammary, Zymbal's, preputial, and clitoral glands. In: Toxicologic Pathology. 2012 ; Vol. 40, No. 6 Suppl.
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