Prokineticin 2 is a target gene of proneural basic helix-loop-helix factors for olfactory bulb neurogenesis

Chengkang Zhang, Kwan Ng, Jia Da Li, Fei He, David J. Anderson, Yi E. Sun, Qun Yong Zhou

Research output: Contribution to journalArticle

32 Scopus citations

Abstract

Prokineticin 2, a cysteine-rich secreted protein, regulates diverse biological functions including the neurogenesis of olfactory bulb. Here we show that the PK2 gene is a functional target gene of proneural basic helix-loop-helix (bHLH) factors. Neurogenin 1 and MASH1 activate PK2 transcription by binding to E-box motifs on the PK2 promoter with the same set of E-boxes critical for another pair of bHLH factors, CLOCK and BMAL1, in the regulation of circadian clock. Our results establish PK2 as a common functional target gene for different bHLH transcriptional factors in mediating their respective functions.

Original languageEnglish (US)
Pages (from-to)6917-6921
Number of pages5
JournalJournal of Biological Chemistry
Volume282
Issue number10
DOIs
StatePublished - Mar 2 2007
Externally publishedYes

ASJC Scopus subject areas

  • Biochemistry
  • Molecular Biology
  • Cell Biology

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