Project Among African-Americans to Explore Risks for schizophrenia (paartners): Evidence for impairment and heritability of Neurocognitive functioning in families of schizophrenia patients

Monica E. Calkins, Ping Tepper, Ruben C. Gur, John D Ragland, Lambertus Klei, Howard W. Wiener, Jan Richard, Robert M. Savage, Trina B. Allen, Judith O'Jile, Bernie Devlin, Joseph Kwentus, Muktar H. Aliyu, L. Dianne Bradford, Neil Edwards, Paul D. Lyons, Vishwajit L. Nimgaonkar, Alberto B. Santos, Rodney C P Go, Raquel E. Gur

Research output: Contribution to journalArticle

49 Citations (Scopus)

Abstract

Objective: Neurocognitive impairments in schizophrenia are well replicated and widely regarded as candidate endophenotypes that may facilitate understanding of schizophrenia genetics and pathophysiology. The Project Among African-Americans to Explore Risks for Schizophrenia (PAARTNERS) aims to identify genes underlying liability to schizophrenia. The unprecedented size of its study group (N=1,872), made possible through use of a computerized neurocognitive battery, can help further investigation of the genetics of neurocognition. The current analysis evaluated two characteristics not fully addressed in prior research: 1) heritability of neurocognition in African American families and 2) relationship between neurocognition and psychopathology in families of African American probands with schizophrenia or schizoaffective disorder. Method: Across eight data collection sites, patients with schizophrenia or schizoaffective disorder (N=610), their biological relatives (N=928), and community comparison subjects (N=334) completed a standardized diagnostic evaluation and the computerized neurocognitive battery. Performance accuracy and response time (speed) were measured separately for 10 neurocognitive domains. Results: The patients with schizophrenia or schizoaffective disorder exhibited less accuracy and speed in most neurocognitive domains than their relatives both with and without other psychiatric disorders, who in turn were more impaired than comparison subjects in most domains. Estimated trait heritability after inclusion of the mean effect of diagnostic status, age, and sex revealed significant heritabilities for most neurocognitive domains, with the highest for accuracy of abstraction/ flexibility, verbal memory, face memory, spatial processing, and emotion processing and for speed of attention. Conclusions: Neurocognitive functions in African American families are heritable and associated with schizophrenia. They show potential for gene-mapping studies.

Original languageEnglish (US)
Pages (from-to)459-472
Number of pages14
JournalAmerican Journal of Psychiatry
Volume167
Issue number4
DOIs
StatePublished - Apr 2010

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African Americans
Schizophrenia
Psychotic Disorders
Endophenotypes
Chromosome Mapping
Psychopathology
Reaction Time
Psychiatry
Emotions
Research
Genes

ASJC Scopus subject areas

  • Psychiatry and Mental health

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Project Among African-Americans to Explore Risks for schizophrenia (paartners) : Evidence for impairment and heritability of Neurocognitive functioning in families of schizophrenia patients. / Calkins, Monica E.; Tepper, Ping; Gur, Ruben C.; Ragland, John D; Klei, Lambertus; Wiener, Howard W.; Richard, Jan; Savage, Robert M.; Allen, Trina B.; O'Jile, Judith; Devlin, Bernie; Kwentus, Joseph; Aliyu, Muktar H.; Bradford, L. Dianne; Edwards, Neil; Lyons, Paul D.; Nimgaonkar, Vishwajit L.; Santos, Alberto B.; Go, Rodney C P; Gur, Raquel E.

In: American Journal of Psychiatry, Vol. 167, No. 4, 04.2010, p. 459-472.

Research output: Contribution to journalArticle

Calkins, ME, Tepper, P, Gur, RC, Ragland, JD, Klei, L, Wiener, HW, Richard, J, Savage, RM, Allen, TB, O'Jile, J, Devlin, B, Kwentus, J, Aliyu, MH, Bradford, LD, Edwards, N, Lyons, PD, Nimgaonkar, VL, Santos, AB, Go, RCP & Gur, RE 2010, 'Project Among African-Americans to Explore Risks for schizophrenia (paartners): Evidence for impairment and heritability of Neurocognitive functioning in families of schizophrenia patients', American Journal of Psychiatry, vol. 167, no. 4, pp. 459-472. https://doi.org/10.1176/appi.ajp.2009.08091351
Calkins, Monica E. ; Tepper, Ping ; Gur, Ruben C. ; Ragland, John D ; Klei, Lambertus ; Wiener, Howard W. ; Richard, Jan ; Savage, Robert M. ; Allen, Trina B. ; O'Jile, Judith ; Devlin, Bernie ; Kwentus, Joseph ; Aliyu, Muktar H. ; Bradford, L. Dianne ; Edwards, Neil ; Lyons, Paul D. ; Nimgaonkar, Vishwajit L. ; Santos, Alberto B. ; Go, Rodney C P ; Gur, Raquel E. / Project Among African-Americans to Explore Risks for schizophrenia (paartners) : Evidence for impairment and heritability of Neurocognitive functioning in families of schizophrenia patients. In: American Journal of Psychiatry. 2010 ; Vol. 167, No. 4. pp. 459-472.
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abstract = "Objective: Neurocognitive impairments in schizophrenia are well replicated and widely regarded as candidate endophenotypes that may facilitate understanding of schizophrenia genetics and pathophysiology. The Project Among African-Americans to Explore Risks for Schizophrenia (PAARTNERS) aims to identify genes underlying liability to schizophrenia. The unprecedented size of its study group (N=1,872), made possible through use of a computerized neurocognitive battery, can help further investigation of the genetics of neurocognition. The current analysis evaluated two characteristics not fully addressed in prior research: 1) heritability of neurocognition in African American families and 2) relationship between neurocognition and psychopathology in families of African American probands with schizophrenia or schizoaffective disorder. Method: Across eight data collection sites, patients with schizophrenia or schizoaffective disorder (N=610), their biological relatives (N=928), and community comparison subjects (N=334) completed a standardized diagnostic evaluation and the computerized neurocognitive battery. Performance accuracy and response time (speed) were measured separately for 10 neurocognitive domains. Results: The patients with schizophrenia or schizoaffective disorder exhibited less accuracy and speed in most neurocognitive domains than their relatives both with and without other psychiatric disorders, who in turn were more impaired than comparison subjects in most domains. Estimated trait heritability after inclusion of the mean effect of diagnostic status, age, and sex revealed significant heritabilities for most neurocognitive domains, with the highest for accuracy of abstraction/ flexibility, verbal memory, face memory, spatial processing, and emotion processing and for speed of attention. Conclusions: Neurocognitive functions in African American families are heritable and associated with schizophrenia. They show potential for gene-mapping studies.",
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T2 - Evidence for impairment and heritability of Neurocognitive functioning in families of schizophrenia patients

AU - Calkins, Monica E.

AU - Tepper, Ping

AU - Gur, Ruben C.

AU - Ragland, John D

AU - Klei, Lambertus

AU - Wiener, Howard W.

AU - Richard, Jan

AU - Savage, Robert M.

AU - Allen, Trina B.

AU - O'Jile, Judith

AU - Devlin, Bernie

AU - Kwentus, Joseph

AU - Aliyu, Muktar H.

AU - Bradford, L. Dianne

AU - Edwards, Neil

AU - Lyons, Paul D.

AU - Nimgaonkar, Vishwajit L.

AU - Santos, Alberto B.

AU - Go, Rodney C P

AU - Gur, Raquel E.

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N2 - Objective: Neurocognitive impairments in schizophrenia are well replicated and widely regarded as candidate endophenotypes that may facilitate understanding of schizophrenia genetics and pathophysiology. The Project Among African-Americans to Explore Risks for Schizophrenia (PAARTNERS) aims to identify genes underlying liability to schizophrenia. The unprecedented size of its study group (N=1,872), made possible through use of a computerized neurocognitive battery, can help further investigation of the genetics of neurocognition. The current analysis evaluated two characteristics not fully addressed in prior research: 1) heritability of neurocognition in African American families and 2) relationship between neurocognition and psychopathology in families of African American probands with schizophrenia or schizoaffective disorder. Method: Across eight data collection sites, patients with schizophrenia or schizoaffective disorder (N=610), their biological relatives (N=928), and community comparison subjects (N=334) completed a standardized diagnostic evaluation and the computerized neurocognitive battery. Performance accuracy and response time (speed) were measured separately for 10 neurocognitive domains. Results: The patients with schizophrenia or schizoaffective disorder exhibited less accuracy and speed in most neurocognitive domains than their relatives both with and without other psychiatric disorders, who in turn were more impaired than comparison subjects in most domains. Estimated trait heritability after inclusion of the mean effect of diagnostic status, age, and sex revealed significant heritabilities for most neurocognitive domains, with the highest for accuracy of abstraction/ flexibility, verbal memory, face memory, spatial processing, and emotion processing and for speed of attention. Conclusions: Neurocognitive functions in African American families are heritable and associated with schizophrenia. They show potential for gene-mapping studies.

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