Progressive transformation of the cytoskeleton associated with normal aging and Alzheimer's disease

James C. Vickers, André Delacourte, John Morrison

Research output: Contribution to journalArticle

90 Scopus citations

Abstract

Transitional and end-stage forms of neurofibrillary tangles associated with normal aging and Alzheimer's disease were identified using thioflavine staining combined with tau and neurofilament protein immunofluorescence. Normal aging was marked by transitional pathology in layer II of the entorhinal cortex but no neurofibrillary tangles in prefrontal cortex, in Alheimer's disease cases, layer II entorhinal neurons had progressed to end-stage neurofibrillary tangles and the prefrontal cortex contained a hign representation of transitional forms of the neurofibrillary tangle.

Original languageEnglish (US)
Pages (from-to)273-278
Number of pages6
JournalBrain Research
Volume594
Issue number2
DOIs
StatePublished - Oct 30 1992
Externally publishedYes

Keywords

  • Aging
  • Alzheimer's disease
  • Dementia
  • Neurofibrillary tangle
  • Neurofilament
  • Tau
  • Thioflavine

ASJC Scopus subject areas

  • Developmental Biology
  • Molecular Biology
  • Clinical Neurology
  • Neuroscience(all)

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