Progressive Immune Dysfunction in Cats Experimentally Infected with Feline Immunodeficiency Virus

Michael Torten, Marco Franchini, Jeffrey E. Barlough, Jeanne W. George, Edna Mozes, Hans Lutz, Niels C Pedersen

Research output: Contribution to journalArticlepeer-review

169 Scopus citations


Within 6 months of infection with the Petaluma isolate of feline immunodeficiency virus, specific-pathogen-free domestic cats exhibited a decrease in the percentage and number of circulating CD4+ lymphocytes and in the CD4+/CD8+ T-cell ratio, along with a marginally significant depression of pokeweed mitogen-induced lymphocyte proliferation in vitro. There was no loss of responsiveness to concanavalin A during this stage, and the cats were capable of mounting a satisfactory antibody response to a T-dependent, synthetic polypeptide immunogen. The pokeweed mitogen response deficit became clearly demonstrable by 11 to 12 months postinfection. A decline in the lymphocyte proliferative response to concanavalin A and a diminished ability to mount an in vivo antibody response to the T-dependent immunogen evolved by 25 to 44 months postinfection. Virus infection did not affect the ability of cats to mount an antibody response to a T-independent synthetic polypeptide immunogen. These data indicate that feline immunodeficiency virus produces a slowly progressive deterioration of T-cell function but does not affect the ability of B cells to recognize and respond to a T-independent antigenic stimulus.

Original languageEnglish (US)
Pages (from-to)2225-2230
Number of pages6
JournalJournal of Virology
Issue number5
StatePublished - May 1991

ASJC Scopus subject areas

  • Immunology


Dive into the research topics of 'Progressive Immune Dysfunction in Cats Experimentally Infected with Feline Immunodeficiency Virus'. Together they form a unique fingerprint.

Cite this