Progressive Immune Dysfunction in Cats Experimentally Infected with Feline Immunodeficiency Virus

Michael Torten, Marco Franchini, Jeffrey E. Barlough, Jeanne W. George, Edna Mozes, Hans Lutz, Niels C Pedersen

Research output: Contribution to journalArticle

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Abstract

Within 6 months of infection with the Petaluma isolate of feline immunodeficiency virus, specific-pathogen-free domestic cats exhibited a decrease in the percentage and number of circulating CD4+ lymphocytes and in the CD4+/CD8+ T-cell ratio, along with a marginally significant depression of pokeweed mitogen-induced lymphocyte proliferation in vitro. There was no loss of responsiveness to concanavalin A during this stage, and the cats were capable of mounting a satisfactory antibody response to a T-dependent, synthetic polypeptide immunogen. The pokeweed mitogen response deficit became clearly demonstrable by 11 to 12 months postinfection. A decline in the lymphocyte proliferative response to concanavalin A and a diminished ability to mount an in vivo antibody response to the T-dependent immunogen evolved by 25 to 44 months postinfection. Virus infection did not affect the ability of cats to mount an antibody response to a T-independent synthetic polypeptide immunogen. These data indicate that feline immunodeficiency virus produces a slowly progressive deterioration of T-cell function but does not affect the ability of B cells to recognize and respond to a T-independent antigenic stimulus.

Original languageEnglish (US)
Pages (from-to)2225-2230
Number of pages6
JournalJournal of Virology
Volume65
Issue number5
StatePublished - May 1991

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Feline Immunodeficiency Virus
Feline immunodeficiency virus
Antibody Formation
Pokeweed Mitogens
Phytolacca americana
Synthetic Vaccines
Cats
Lymphocytes
cats
concanavalin A
Concanavalin A
antigens
antibodies
polypeptides
lymphocytes
T-lymphocytes
T-Lymphocytes
Specific Pathogen-Free Organisms
Peptides
Virus Diseases

ASJC Scopus subject areas

  • Immunology

Cite this

Torten, M., Franchini, M., Barlough, J. E., George, J. W., Mozes, E., Lutz, H., & Pedersen, N. C. (1991). Progressive Immune Dysfunction in Cats Experimentally Infected with Feline Immunodeficiency Virus. Journal of Virology, 65(5), 2225-2230.

Progressive Immune Dysfunction in Cats Experimentally Infected with Feline Immunodeficiency Virus. / Torten, Michael; Franchini, Marco; Barlough, Jeffrey E.; George, Jeanne W.; Mozes, Edna; Lutz, Hans; Pedersen, Niels C.

In: Journal of Virology, Vol. 65, No. 5, 05.1991, p. 2225-2230.

Research output: Contribution to journalArticle

Torten, M, Franchini, M, Barlough, JE, George, JW, Mozes, E, Lutz, H & Pedersen, NC 1991, 'Progressive Immune Dysfunction in Cats Experimentally Infected with Feline Immunodeficiency Virus', Journal of Virology, vol. 65, no. 5, pp. 2225-2230.
Torten M, Franchini M, Barlough JE, George JW, Mozes E, Lutz H et al. Progressive Immune Dysfunction in Cats Experimentally Infected with Feline Immunodeficiency Virus. Journal of Virology. 1991 May;65(5):2225-2230.
Torten, Michael ; Franchini, Marco ; Barlough, Jeffrey E. ; George, Jeanne W. ; Mozes, Edna ; Lutz, Hans ; Pedersen, Niels C. / Progressive Immune Dysfunction in Cats Experimentally Infected with Feline Immunodeficiency Virus. In: Journal of Virology. 1991 ; Vol. 65, No. 5. pp. 2225-2230.
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