Abstract
Within 6 months of infection with the Petaluma isolate of feline immunodeficiency virus, specific-pathogen-free domestic cats exhibited a decrease in the percentage and number of circulating CD4+ lymphocytes and in the CD4+/CD8+ T-cell ratio, along with a marginally significant depression of pokeweed mitogen-induced lymphocyte proliferation in vitro. There was no loss of responsiveness to concanavalin A during this stage, and the cats were capable of mounting a satisfactory antibody response to a T-dependent, synthetic polypeptide immunogen. The pokeweed mitogen response deficit became clearly demonstrable by 11 to 12 months postinfection. A decline in the lymphocyte proliferative response to concanavalin A and a diminished ability to mount an in vivo antibody response to the T-dependent immunogen evolved by 25 to 44 months postinfection. Virus infection did not affect the ability of cats to mount an antibody response to a T-independent synthetic polypeptide immunogen. These data indicate that feline immunodeficiency virus produces a slowly progressive deterioration of T-cell function but does not affect the ability of B cells to recognize and respond to a T-independent antigenic stimulus.
| Original language | English (US) |
|---|---|
| Pages (from-to) | 2225-2230 |
| Number of pages | 6 |
| Journal | Journal of Virology |
| Volume | 65 |
| Issue number | 5 |
| State | Published - May 1991 |
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ASJC Scopus subject areas
- Immunology
Cite this
Progressive Immune Dysfunction in Cats Experimentally Infected with Feline Immunodeficiency Virus. / Torten, Michael; Franchini, Marco; Barlough, Jeffrey E.; George, Jeanne W.; Mozes, Edna; Lutz, Hans; Pedersen, Niels C.
In: Journal of Virology, Vol. 65, No. 5, 05.1991, p. 2225-2230.Research output: Contribution to journal › Article
}
TY - JOUR
T1 - Progressive Immune Dysfunction in Cats Experimentally Infected with Feline Immunodeficiency Virus
AU - Torten, Michael
AU - Franchini, Marco
AU - Barlough, Jeffrey E.
AU - George, Jeanne W.
AU - Mozes, Edna
AU - Lutz, Hans
AU - Pedersen, Niels C
PY - 1991/5
Y1 - 1991/5
N2 - Within 6 months of infection with the Petaluma isolate of feline immunodeficiency virus, specific-pathogen-free domestic cats exhibited a decrease in the percentage and number of circulating CD4+ lymphocytes and in the CD4+/CD8+ T-cell ratio, along with a marginally significant depression of pokeweed mitogen-induced lymphocyte proliferation in vitro. There was no loss of responsiveness to concanavalin A during this stage, and the cats were capable of mounting a satisfactory antibody response to a T-dependent, synthetic polypeptide immunogen. The pokeweed mitogen response deficit became clearly demonstrable by 11 to 12 months postinfection. A decline in the lymphocyte proliferative response to concanavalin A and a diminished ability to mount an in vivo antibody response to the T-dependent immunogen evolved by 25 to 44 months postinfection. Virus infection did not affect the ability of cats to mount an antibody response to a T-independent synthetic polypeptide immunogen. These data indicate that feline immunodeficiency virus produces a slowly progressive deterioration of T-cell function but does not affect the ability of B cells to recognize and respond to a T-independent antigenic stimulus.
AB - Within 6 months of infection with the Petaluma isolate of feline immunodeficiency virus, specific-pathogen-free domestic cats exhibited a decrease in the percentage and number of circulating CD4+ lymphocytes and in the CD4+/CD8+ T-cell ratio, along with a marginally significant depression of pokeweed mitogen-induced lymphocyte proliferation in vitro. There was no loss of responsiveness to concanavalin A during this stage, and the cats were capable of mounting a satisfactory antibody response to a T-dependent, synthetic polypeptide immunogen. The pokeweed mitogen response deficit became clearly demonstrable by 11 to 12 months postinfection. A decline in the lymphocyte proliferative response to concanavalin A and a diminished ability to mount an in vivo antibody response to the T-dependent immunogen evolved by 25 to 44 months postinfection. Virus infection did not affect the ability of cats to mount an antibody response to a T-independent synthetic polypeptide immunogen. These data indicate that feline immunodeficiency virus produces a slowly progressive deterioration of T-cell function but does not affect the ability of B cells to recognize and respond to a T-independent antigenic stimulus.
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UR - http://www.scopus.com/inward/citedby.url?scp=0025864145&partnerID=8YFLogxK
M3 - Article
VL - 65
SP - 2225
EP - 2230
JO - Journal of Virology
JF - Journal of Virology
SN - 0022-538X
IS - 5
ER -