Abstract
Recent data suggest that DKA may contribute to cognitive impairment in children with type 1 DM. We measured the NAA/Cr ratio in a teenager during and following 2 separate episodes of DKA without clinically apparent cerebral edema. The NAA/Cr ratio decreased during DKA and improved following recovery. However, the NAA/Cr value was lower after the second episode of DKA (1.76) than after the first (1.97). These findings provide support for the hypothesis that neuronal injury may result from DKA.
| Original language | English (US) |
|---|---|
| Pages (from-to) | 780-781 |
| Number of pages | 2 |
| Journal | American Journal of Neuroradiology |
| Volume | 31 |
| Issue number | 4 |
| DOIs | |
| State | Published - Apr 2010 |
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ASJC Scopus subject areas
- Clinical Neurology
- Radiology Nuclear Medicine and imaging
Cite this
Progressive decrease in N-acetylaspartate/creatine ratio in a teenager with type 1 diabetes and repeated episodes of ketoacidosis without clinically apparent cerebral edema : Evidence for permanent brain injury. / Wootton-Gorges, Sandra L.; Buonocore, M. H.; Caltagirone, R. A.; Kuppermann, Nathan; Glaser, Nicole.
In: American Journal of Neuroradiology, Vol. 31, No. 4, 04.2010, p. 780-781.Research output: Contribution to journal › Article
}
TY - JOUR
T1 - Progressive decrease in N-acetylaspartate/creatine ratio in a teenager with type 1 diabetes and repeated episodes of ketoacidosis without clinically apparent cerebral edema
T2 - Evidence for permanent brain injury
AU - Wootton-Gorges, Sandra L.
AU - Buonocore, M. H.
AU - Caltagirone, R. A.
AU - Kuppermann, Nathan
AU - Glaser, Nicole
PY - 2010/4
Y1 - 2010/4
N2 - Recent data suggest that DKA may contribute to cognitive impairment in children with type 1 DM. We measured the NAA/Cr ratio in a teenager during and following 2 separate episodes of DKA without clinically apparent cerebral edema. The NAA/Cr ratio decreased during DKA and improved following recovery. However, the NAA/Cr value was lower after the second episode of DKA (1.76) than after the first (1.97). These findings provide support for the hypothesis that neuronal injury may result from DKA.
AB - Recent data suggest that DKA may contribute to cognitive impairment in children with type 1 DM. We measured the NAA/Cr ratio in a teenager during and following 2 separate episodes of DKA without clinically apparent cerebral edema. The NAA/Cr ratio decreased during DKA and improved following recovery. However, the NAA/Cr value was lower after the second episode of DKA (1.76) than after the first (1.97). These findings provide support for the hypothesis that neuronal injury may result from DKA.
UR - http://www.scopus.com/inward/record.url?scp=77950848193&partnerID=8YFLogxK
UR - http://www.scopus.com/inward/citedby.url?scp=77950848193&partnerID=8YFLogxK
U2 - 10.3174/ajnr.A1829
DO - 10.3174/ajnr.A1829
M3 - Article
C2 - 19926705
AN - SCOPUS:77950848193
VL - 31
SP - 780
EP - 781
JO - American Journal of Neuroradiology
JF - American Journal of Neuroradiology
SN - 0195-6108
IS - 4
ER -