Progressive decrease in N-acetylaspartate/creatine ratio in a teenager with type 1 diabetes and repeated episodes of ketoacidosis without clinically apparent cerebral edema: Evidence for permanent brain injury

Sandra L. Wootton-Gorges; M. H. Buonocore; R. A. Caltagirone; Nathan Kuppermann; Nicole Glaser

doi:10.3174/ajnr.A1829

Progressive decrease in N-acetylaspartate/creatine ratio in a teenager with type 1 diabetes and repeated episodes of ketoacidosis without clinically apparent cerebral edema: Evidence for permanent brain injury

Sandra L. Wootton-Gorges, M. H. Buonocore, R. A. Caltagirone, Nathan Kuppermann, Nicole Glaser

Research output: Contribution to journal › Article

13 Scopus citations

Abstract

Recent data suggest that DKA may contribute to cognitive impairment in children with type 1 DM. We measured the NAA/Cr ratio in a teenager during and following 2 separate episodes of DKA without clinically apparent cerebral edema. The NAA/Cr ratio decreased during DKA and improved following recovery. However, the NAA/Cr value was lower after the second episode of DKA (1.76) than after the first (1.97). These findings provide support for the hypothesis that neuronal injury may result from DKA.

Original language	English (US)
Pages (from-to)	780-781
Number of pages	2
Journal	American Journal of Neuroradiology
Volume	31
Issue number	4
DOIs	https://doi.org/10.3174/ajnr.A1829
State	Published - Apr 2010

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ASJC Scopus subject areas

Clinical Neurology
Radiology Nuclear Medicine and imaging

Cite this

Wootton-Gorges, S. L., Buonocore, M. H., Caltagirone, R. A., Kuppermann, N., & Glaser, N. (2010). Progressive decrease in N-acetylaspartate/creatine ratio in a teenager with type 1 diabetes and repeated episodes of ketoacidosis without clinically apparent cerebral edema: Evidence for permanent brain injury. American Journal of Neuroradiology, 31(4), 780-781. https://doi.org/10.3174/ajnr.A1829

Progressive decrease in N-acetylaspartate/creatine ratio in a teenager with type 1 diabetes and repeated episodes of ketoacidosis without clinically apparent cerebral edema : Evidence for permanent brain injury. / Wootton-Gorges, Sandra L.; Buonocore, M. H.; Caltagirone, R. A.; Kuppermann, Nathan ; Glaser, Nicole.

In: American Journal of Neuroradiology, Vol. 31, No. 4, 04.2010, p. 780-781.

Research output: Contribution to journal › Article

Wootton-Gorges, SL, Buonocore, MH, Caltagirone, RA, Kuppermann, N & Glaser, N 2010, 'Progressive decrease in N-acetylaspartate/creatine ratio in a teenager with type 1 diabetes and repeated episodes of ketoacidosis without clinically apparent cerebral edema: Evidence for permanent brain injury', American Journal of Neuroradiology, vol. 31, no. 4, pp. 780-781. https://doi.org/10.3174/ajnr.A1829

Wootton-Gorges SL, Buonocore MH, Caltagirone RA, Kuppermann N , Glaser N. Progressive decrease in N-acetylaspartate/creatine ratio in a teenager with type 1 diabetes and repeated episodes of ketoacidosis without clinically apparent cerebral edema: Evidence for permanent brain injury. American Journal of Neuroradiology. 2010 Apr;31(4):780-781. https://doi.org/10.3174/ajnr.A1829

Wootton-Gorges, Sandra L. ; Buonocore, M. H. ; Caltagirone, R. A. ; Kuppermann, Nathan ; Glaser, Nicole. / Progressive decrease in N-acetylaspartate/creatine ratio in a teenager with type 1 diabetes and repeated episodes of ketoacidosis without clinically apparent cerebral edema : Evidence for permanent brain injury. In: American Journal of Neuroradiology. 2010 ; Vol. 31, No. 4. pp. 780-781.

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