Progressive decrease in N-acetylaspartate/creatine ratio in a teenager with type 1 diabetes and repeated episodes of ketoacidosis without clinically apparent cerebral edema: Evidence for permanent brain injury

Sandra L. Wootton-Gorges, M. H. Buonocore, R. A. Caltagirone, Nathan Kuppermann, Nicole Glaser

Research output: Contribution to journalArticle

11 Citations (Scopus)

Abstract

Recent data suggest that DKA may contribute to cognitive impairment in children with type 1 DM. We measured the NAA/Cr ratio in a teenager during and following 2 separate episodes of DKA without clinically apparent cerebral edema. The NAA/Cr ratio decreased during DKA and improved following recovery. However, the NAA/Cr value was lower after the second episode of DKA (1.76) than after the first (1.97). These findings provide support for the hypothesis that neuronal injury may result from DKA.

Original languageEnglish (US)
Pages (from-to)780-781
Number of pages2
JournalAmerican Journal of Neuroradiology
Volume31
Issue number4
DOIs
StatePublished - Apr 2010

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Ketosis
Creatine
Brain Edema
Type 1 Diabetes Mellitus
Brain Injuries
Wounds and Injuries
Cognitive Dysfunction
N-acetylaspartate

ASJC Scopus subject areas

  • Clinical Neurology
  • Radiology Nuclear Medicine and imaging

Cite this

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abstract = "Recent data suggest that DKA may contribute to cognitive impairment in children with type 1 DM. We measured the NAA/Cr ratio in a teenager during and following 2 separate episodes of DKA without clinically apparent cerebral edema. The NAA/Cr ratio decreased during DKA and improved following recovery. However, the NAA/Cr value was lower after the second episode of DKA (1.76) than after the first (1.97). These findings provide support for the hypothesis that neuronal injury may result from DKA.",
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AU - Glaser, Nicole

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