Progression of prostate cancer

Multiple pathways to androgen independence

Hong Lin Devlin, Maria Mudryj

Research output: Contribution to journalArticle

79 Citations (Scopus)

Abstract

Prostate cancer remains one of the most commonly diagnosed cancers and a leading cause of cancer death in men. Initially, prostate tumors respond to hormonal therapies, but androgen-independent tumors refractory to these therapies emerge. Identifying the mechanisms responsible for the emergence of androgen independence has been the subject of multiple studies. This article reviews the multiple pathways that have been shown to promote androgen independence, including a recently described mechanism that involves androgen receptor proteolysis to a constitutively active ligand-independent isoform. Identifying the underlying mechanisms of androgen independence is crucial in the design of appropriate therapies for hormonally refractive neoplasms.

Original languageEnglish (US)
Pages (from-to)177-186
Number of pages10
JournalCancer Letters
Volume274
Issue number2
DOIs
StatePublished - Feb 18 2009

Fingerprint

Androgens
Prostatic Neoplasms
Neoplasms
Androgen Receptors
Proteolysis
Prostate
Cause of Death
Protein Isoforms
Therapeutics
Ligands

Keywords

  • Androgen independence
  • Androgen receptor
  • Calpain
  • Prostate cancer
  • Signaling

ASJC Scopus subject areas

  • Cancer Research
  • Oncology

Cite this

Progression of prostate cancer : Multiple pathways to androgen independence. / Devlin, Hong Lin; Mudryj, Maria.

In: Cancer Letters, Vol. 274, No. 2, 18.02.2009, p. 177-186.

Research output: Contribution to journalArticle

@article{c69935b47dbd47d582aae5bb77e2e1a4,
title = "Progression of prostate cancer: Multiple pathways to androgen independence",
abstract = "Prostate cancer remains one of the most commonly diagnosed cancers and a leading cause of cancer death in men. Initially, prostate tumors respond to hormonal therapies, but androgen-independent tumors refractory to these therapies emerge. Identifying the mechanisms responsible for the emergence of androgen independence has been the subject of multiple studies. This article reviews the multiple pathways that have been shown to promote androgen independence, including a recently described mechanism that involves androgen receptor proteolysis to a constitutively active ligand-independent isoform. Identifying the underlying mechanisms of androgen independence is crucial in the design of appropriate therapies for hormonally refractive neoplasms.",
keywords = "Androgen independence, Androgen receptor, Calpain, Prostate cancer, Signaling",
author = "Devlin, {Hong Lin} and Maria Mudryj",
year = "2009",
month = "2",
day = "18",
doi = "10.1016/j.canlet.2008.06.007",
language = "English (US)",
volume = "274",
pages = "177--186",
journal = "Cancer Letters",
issn = "0304-3835",
publisher = "Elsevier Ireland Ltd",
number = "2",

}

TY - JOUR

T1 - Progression of prostate cancer

T2 - Multiple pathways to androgen independence

AU - Devlin, Hong Lin

AU - Mudryj, Maria

PY - 2009/2/18

Y1 - 2009/2/18

N2 - Prostate cancer remains one of the most commonly diagnosed cancers and a leading cause of cancer death in men. Initially, prostate tumors respond to hormonal therapies, but androgen-independent tumors refractory to these therapies emerge. Identifying the mechanisms responsible for the emergence of androgen independence has been the subject of multiple studies. This article reviews the multiple pathways that have been shown to promote androgen independence, including a recently described mechanism that involves androgen receptor proteolysis to a constitutively active ligand-independent isoform. Identifying the underlying mechanisms of androgen independence is crucial in the design of appropriate therapies for hormonally refractive neoplasms.

AB - Prostate cancer remains one of the most commonly diagnosed cancers and a leading cause of cancer death in men. Initially, prostate tumors respond to hormonal therapies, but androgen-independent tumors refractory to these therapies emerge. Identifying the mechanisms responsible for the emergence of androgen independence has been the subject of multiple studies. This article reviews the multiple pathways that have been shown to promote androgen independence, including a recently described mechanism that involves androgen receptor proteolysis to a constitutively active ligand-independent isoform. Identifying the underlying mechanisms of androgen independence is crucial in the design of appropriate therapies for hormonally refractive neoplasms.

KW - Androgen independence

KW - Androgen receptor

KW - Calpain

KW - Prostate cancer

KW - Signaling

UR - http://www.scopus.com/inward/record.url?scp=58149302446&partnerID=8YFLogxK

UR - http://www.scopus.com/inward/citedby.url?scp=58149302446&partnerID=8YFLogxK

U2 - 10.1016/j.canlet.2008.06.007

DO - 10.1016/j.canlet.2008.06.007

M3 - Article

VL - 274

SP - 177

EP - 186

JO - Cancer Letters

JF - Cancer Letters

SN - 0304-3835

IS - 2

ER -