Progression of prostate cancer: Multiple pathways to androgen independence

Hong Lin Devlin, Maria Mudryj

Research output: Contribution to journalArticle

81 Scopus citations

Abstract

Prostate cancer remains one of the most commonly diagnosed cancers and a leading cause of cancer death in men. Initially, prostate tumors respond to hormonal therapies, but androgen-independent tumors refractory to these therapies emerge. Identifying the mechanisms responsible for the emergence of androgen independence has been the subject of multiple studies. This article reviews the multiple pathways that have been shown to promote androgen independence, including a recently described mechanism that involves androgen receptor proteolysis to a constitutively active ligand-independent isoform. Identifying the underlying mechanisms of androgen independence is crucial in the design of appropriate therapies for hormonally refractive neoplasms.

Original languageEnglish (US)
Pages (from-to)177-186
Number of pages10
JournalCancer Letters
Volume274
Issue number2
DOIs
StatePublished - Feb 18 2009

Keywords

  • Androgen independence
  • Androgen receptor
  • Calpain
  • Prostate cancer
  • Signaling

ASJC Scopus subject areas

  • Cancer Research
  • Oncology

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