Progress Toward Hormonal Therapy of Gastrointestinal Cancer

Richard J Bold, Jin Ishizuka, Courtney M. Townsend

Research output: Contribution to journalArticle

14 Citations (Scopus)

Abstract

Objective The authors discuss ongoing research to determine the mechanisms by which peptide hormones regulate growth of gastrointestinal cancer and ways in which this information might be used to develop noncytotoxic therapy. Summary Background Approximately 100,000 people die of cancer of the gastrointestinal (GI) tract each year. Surgery is curative only when the tumor is localized. Chemotherapy and radiotherapy have limited efficacy for locally advanced or widespread disease. Various peptide hormones regulate the growth of these tumors. As for breast and prostate cancer, the growth regulatory effect of these hormones is being studied as a potential mechanism of hormonal therapy. Conclusion Gut peptide hormones regulate the growth of GI malignancies through all-specific receptors and signal transduction pathways. Interruption or modification of these growth regulatory mechanisms may lead to specific noncytotoxic therapy. In combination with surgical extirpation, such hormonally based treatment may be curative of advanced GI cancer.

Original languageEnglish (US)
Pages (from-to)4-11
Number of pages8
JournalAnnals of Surgery
Volume223
Issue number1
StatePublished - 1996

Fingerprint

Gastrointestinal Neoplasms
Peptide Hormones
Growth
Therapeutics
Neoplasms
Signal Transduction
Prostatic Neoplasms
Radiotherapy
Hormones
Breast Neoplasms
Drug Therapy
Research

ASJC Scopus subject areas

  • Surgery

Cite this

Bold, R. J., Ishizuka, J., & Townsend, C. M. (1996). Progress Toward Hormonal Therapy of Gastrointestinal Cancer. Annals of Surgery, 223(1), 4-11.

Progress Toward Hormonal Therapy of Gastrointestinal Cancer. / Bold, Richard J; Ishizuka, Jin; Townsend, Courtney M.

In: Annals of Surgery, Vol. 223, No. 1, 1996, p. 4-11.

Research output: Contribution to journalArticle

Bold, RJ, Ishizuka, J & Townsend, CM 1996, 'Progress Toward Hormonal Therapy of Gastrointestinal Cancer', Annals of Surgery, vol. 223, no. 1, pp. 4-11.
Bold, Richard J ; Ishizuka, Jin ; Townsend, Courtney M. / Progress Toward Hormonal Therapy of Gastrointestinal Cancer. In: Annals of Surgery. 1996 ; Vol. 223, No. 1. pp. 4-11.
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