Abstract
We present a new design for a wavefront sensorless adaptive optics (WS-AO) Fourier domain optical coherence tomography (FD-OCT) system for small animal retinal imaging in vivo. Without the optical complications necessary for inclusion of a wavefront sensor in the optical system, this version of WS-AO FD-OCT system has a simplified optical design, including elimination of long focal length scanning optics and optical conjugation of vertical and horizontal scanners. This modification provides a modular large Field of View for retinal screening (25 degree visual angle), while also allowing a "zoom" capability for allocating all the scanning resources to a smaller region of interest, allowing high resolution aberration-corrected imaging. In the present system we used a 0 Dpt contact lens to stabilize the mouse eye position and to allow long duration imaging. Defocus (axial focus position) in our system is controlled by the collimation of the OCT sample arm entrance beam.
Original language | English (US) |
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Title of host publication | Progress in Biomedical Optics and Imaging - Proceedings of SPIE |
Publisher | SPIE |
Volume | 9312 |
ISBN (Print) | 9781628414028 |
DOIs | |
State | Published - 2015 |
Event | Optical Coherence Tomography and Coherence Domain Optical Methods in Biomedicine XIX - San Francisco, United States Duration: Feb 8 2015 → Feb 11 2015 |
Other
Other | Optical Coherence Tomography and Coherence Domain Optical Methods in Biomedicine XIX |
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Country/Territory | United States |
City | San Francisco |
Period | 2/8/15 → 2/11/15 |
Keywords
- Adaptive optics
- Animal models
- Imaging system
- Medical optics instrumentation
- Ophthalmology
- Optical coherence tomography
ASJC Scopus subject areas
- Atomic and Molecular Physics, and Optics
- Electronic, Optical and Magnetic Materials
- Biomaterials
- Radiology Nuclear Medicine and imaging