Progress in periventricular leukomalacia

Wenbin Deng, Jeanette Pleasure, David E Pleasure

Research output: Contribution to journalArticle

104 Citations (Scopus)

Abstract

Periventricular leukomalacia (PVL) is the predominant form of brain injury and the leading known cause of cerebral palsy and cognitive deficits in premature infants. The number of low-birth-weight infants who survive to demonstrate these neurologic deficts is increasing. Magnetic resonance imaging-based neuroimaging techniques provide greater diagnostic sensitivity for PVL than does head ultrasonography and often document the involvement of telencephalic gray matter and long tracts in addition to periventricular white matter. The neuropathologic hallmarks of PVL are microglial activation and focal and diffuse periventricular depletion of premyelinating oligodendroglia. Premyelinating oligodendroglia are highly vulnerable to death caused by glutamate, free radicals, and proinflammatory cytokines. Studies in animal models of PVL suggest that pharmacologic interventions that target these toxic molecules will be useful in diminishing the severity of PVL.

Original languageEnglish (US)
Pages (from-to)1291-1295
Number of pages5
JournalArchives of Neurology
Volume65
Issue number10
DOIs
StatePublished - Oct 2008

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Periventricular Leukomalacia
Oligodendroglia
Telencephalon
Poisons
Low Birth Weight Infant
Cerebral Palsy
Premature Infants
Neuroimaging
Brain Injuries
Nervous System
Free Radicals
Glutamic Acid
Ultrasonography
Animal Models
Head
Magnetic Resonance Imaging
Cytokines
Brain Injury
Diagnostics
Causes

ASJC Scopus subject areas

  • Clinical Neurology

Cite this

Progress in periventricular leukomalacia. / Deng, Wenbin; Pleasure, Jeanette; Pleasure, David E.

In: Archives of Neurology, Vol. 65, No. 10, 10.2008, p. 1291-1295.

Research output: Contribution to journalArticle

Deng, Wenbin ; Pleasure, Jeanette ; Pleasure, David E. / Progress in periventricular leukomalacia. In: Archives of Neurology. 2008 ; Vol. 65, No. 10. pp. 1291-1295.
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