Progress in measurements and interpretation of light-evoked retinal function using OCT based optoretinography (ORG)

Robert J. Zawadzki; Pengfei Zhang; Ewelina Pijewska; Denise Valente; Ratheesh K. Meleppat; Kari V. Vienola; Sarah J. Karlen; M. Szkulmowski; John S. Werner; Edward N. Pugh; Ravi S. Jonnal

doi:10.1117/12.2616045

Progress in measurements and interpretation of light-evoked retinal function using OCT based optoretinography (ORG)

Robert J. Zawadzki, Pengfei Zhang, Ewelina Pijewska, Denise Valente, Ratheesh K. Meleppat, Kari V. Vienola, Sarah J. Karlen, M. Szkulmowski, John S. Werner, Edward N. Pugh, Ravi S. Jonnal

Research output: Chapter in Book/Report/Conference proceeding › Conference contribution

Abstract

The development of functional retinal imaging is of great interest to clinical and experimental ophthalmology, because it should provide more sensitive tools for ocular diseases diagnostic that would go beyond current gold standard of simple evaluation of the static retinal morphology. In this presentation we will review our recent progress in measurements and interpretation of OCT-based optoretinograms (ORG) i.e., the paradigm of using NIR OCT to measure in vivo bleaching-induced changes in retinal morphology (transient changes in volume of individual neurons, or thickness of retinal layers). Specifically, comparison between different instrumentations used to acquire ORGs and between results acquired using clinical (human) and experimental (animal) systems will be presented. Additionally, intensity-based and phase-based ORG extraction framework will be presented. Finally, we will discuss our findings in the context of current understanding of measured process, being a result osmotically driven water movements between the photoreceptors, and other retinal neurons and its surroundings.

Original language	English (US)
Title of host publication	Optical Coherence Imaging Techniques and Imaging in Scattering Media IV
Editors	Benjamin J. Vakoc, Maciej Wojtkowski, Yoshiaki Yasuno
Publisher	SPIE
ISBN (Electronic)	9781510647145
DOIs	https://doi.org/10.1117/12.2616045
State	Published - 2021
Event	Optical Coherence Imaging Techniques and Imaging in Scattering Media IV 2021 - Virtual, Online, Germany Duration: Jun 20 2021 → Jun 24 2021

Publication series

Name	Progress in Biomedical Optics and Imaging - Proceedings of SPIE
Volume	11924
ISSN (Print)	1605-7422

Conference

Conference	Optical Coherence Imaging Techniques and Imaging in Scattering Media IV 2021
Country/Territory	Germany
City	Virtual, Online
Period	6/20/21 → 6/24/21

ASJC Scopus subject areas

Electronic, Optical and Magnetic Materials
Atomic and Molecular Physics, and Optics
Biomaterials
Radiology Nuclear Medicine and imaging

Access to Document

10.1117/12.2616045

Cite this

Zawadzki, R. J., Zhang, P., Pijewska, E., Valente, D., Meleppat, R. K., Vienola, K. V., Karlen, S. J., Szkulmowski, M., Werner, J. S., Pugh, E. N., & Jonnal, R. S. (2021). Progress in measurements and interpretation of light-evoked retinal function using OCT based optoretinography (ORG). In B. J. Vakoc, M. Wojtkowski, & Y. Yasuno (Eds.), Optical Coherence Imaging Techniques and Imaging in Scattering Media IV [119240M] (Progress in Biomedical Optics and Imaging - Proceedings of SPIE; Vol. 11924). SPIE. https://doi.org/10.1117/12.2616045

Progress in measurements and interpretation of light-evoked retinal function using OCT based optoretinography (ORG). / Zawadzki, Robert J.; Zhang, Pengfei; Pijewska, Ewelina; Valente, Denise; Meleppat, Ratheesh K.; Vienola, Kari V.; Karlen, Sarah J.; Szkulmowski, M.; Werner, John S.; Pugh, Edward N.; Jonnal, Ravi S.

Optical Coherence Imaging Techniques and Imaging in Scattering Media IV. ed. / Benjamin J. Vakoc; Maciej Wojtkowski; Yoshiaki Yasuno. SPIE, 2021. 119240M (Progress in Biomedical Optics and Imaging - Proceedings of SPIE; Vol. 11924).

Research output: Chapter in Book/Report/Conference proceeding › Conference contribution

Zawadzki, RJ, Zhang, P, Pijewska, E, Valente, D, Meleppat, RK, Vienola, KV, Karlen, SJ, Szkulmowski, M, Werner, JS , Pugh, EN & Jonnal, RS 2021, Progress in measurements and interpretation of light-evoked retinal function using OCT based optoretinography (ORG). in BJ Vakoc, M Wojtkowski & Y Yasuno (eds), Optical Coherence Imaging Techniques and Imaging in Scattering Media IV., 119240M, Progress in Biomedical Optics and Imaging - Proceedings of SPIE, vol. 11924, SPIE, Optical Coherence Imaging Techniques and Imaging in Scattering Media IV 2021, Virtual, Online, Germany, 6/20/21. https://doi.org/10.1117/12.2616045

Zawadzki RJ, Zhang P, Pijewska E, Valente D, Meleppat RK, Vienola KV et al. Progress in measurements and interpretation of light-evoked retinal function using OCT based optoretinography (ORG). In Vakoc BJ, Wojtkowski M, Yasuno Y, editors, Optical Coherence Imaging Techniques and Imaging in Scattering Media IV. SPIE. 2021. 119240M. (Progress in Biomedical Optics and Imaging - Proceedings of SPIE). https://doi.org/10.1117/12.2616045

Zawadzki, Robert J. ; Zhang, Pengfei ; Pijewska, Ewelina ; Valente, Denise ; Meleppat, Ratheesh K. ; Vienola, Kari V. ; Karlen, Sarah J. ; Szkulmowski, M. ; Werner, John S. ; Pugh, Edward N. ; Jonnal, Ravi S. / Progress in measurements and interpretation of light-evoked retinal function using OCT based optoretinography (ORG). Optical Coherence Imaging Techniques and Imaging in Scattering Media IV. editor / Benjamin J. Vakoc ; Maciej Wojtkowski ; Yoshiaki Yasuno. SPIE, 2021. (Progress in Biomedical Optics and Imaging - Proceedings of SPIE).

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title = "Progress in measurements and interpretation of light-evoked retinal function using OCT based optoretinography (ORG)",

abstract = "The development of functional retinal imaging is of great interest to clinical and experimental ophthalmology, because it should provide more sensitive tools for ocular diseases diagnostic that would go beyond current gold standard of simple evaluation of the static retinal morphology. In this presentation we will review our recent progress in measurements and interpretation of OCT-based optoretinograms (ORG) i.e., the paradigm of using NIR OCT to measure in vivo bleaching-induced changes in retinal morphology (transient changes in volume of individual neurons, or thickness of retinal layers). Specifically, comparison between different instrumentations used to acquire ORGs and between results acquired using clinical (human) and experimental (animal) systems will be presented. Additionally, intensity-based and phase-based ORG extraction framework will be presented. Finally, we will discuss our findings in the context of current understanding of measured process, being a result osmotically driven water movements between the photoreceptors, and other retinal neurons and its surroundings. ",

author = "Zawadzki, {Robert J.} and Pengfei Zhang and Ewelina Pijewska and Denise Valente and Meleppat, {Ratheesh K.} and Vienola, {Kari V.} and Karlen, {Sarah J.} and M. Szkulmowski and Werner, {John S.} and Pugh, {Edward N.} and Jonnal, {Ravi S.}",

note = "Funding Information: We thank UC Davis EyePod as well VSRI UC Davis Laboratory members, for help and support. This research was partially supported by NIH grants EY026556; EY031098 (RJZ), EY02660 (ENP), EY012576 (NEI Core Grant) and TEAM TECH program of the Foundation for Polish Science co-financed by the European Union under the European Regional Development Fund (POIR.04.04.00-00-2070/16-00) (MS) Publisher Copyright: {\textcopyright} COPYRIGHT SPIE. Downloading of the abstract is permitted for personal use only.; Optical Coherence Imaging Techniques and Imaging in Scattering Media IV 2021 ; Conference date: 20-06-2021 Through 24-06-2021",

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doi = "10.1117/12.2616045",

language = "English (US)",

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AU - Valente, Denise

AU - Meleppat, Ratheesh K.

AU - Vienola, Kari V.

AU - Karlen, Sarah J.

AU - Szkulmowski, M.

AU - Werner, John S.

AU - Pugh, Edward N.

AU - Jonnal, Ravi S.

N1 - Funding Information: We thank UC Davis EyePod as well VSRI UC Davis Laboratory members, for help and support. This research was partially supported by NIH grants EY026556; EY031098 (RJZ), EY02660 (ENP), EY012576 (NEI Core Grant) and TEAM TECH program of the Foundation for Polish Science co-financed by the European Union under the European Regional Development Fund (POIR.04.04.00-00-2070/16-00) (MS) Publisher Copyright: © COPYRIGHT SPIE. Downloading of the abstract is permitted for personal use only.

PY - 2021

Y1 - 2021

N2 - The development of functional retinal imaging is of great interest to clinical and experimental ophthalmology, because it should provide more sensitive tools for ocular diseases diagnostic that would go beyond current gold standard of simple evaluation of the static retinal morphology. In this presentation we will review our recent progress in measurements and interpretation of OCT-based optoretinograms (ORG) i.e., the paradigm of using NIR OCT to measure in vivo bleaching-induced changes in retinal morphology (transient changes in volume of individual neurons, or thickness of retinal layers). Specifically, comparison between different instrumentations used to acquire ORGs and between results acquired using clinical (human) and experimental (animal) systems will be presented. Additionally, intensity-based and phase-based ORG extraction framework will be presented. Finally, we will discuss our findings in the context of current understanding of measured process, being a result osmotically driven water movements between the photoreceptors, and other retinal neurons and its surroundings.

AB - The development of functional retinal imaging is of great interest to clinical and experimental ophthalmology, because it should provide more sensitive tools for ocular diseases diagnostic that would go beyond current gold standard of simple evaluation of the static retinal morphology. In this presentation we will review our recent progress in measurements and interpretation of OCT-based optoretinograms (ORG) i.e., the paradigm of using NIR OCT to measure in vivo bleaching-induced changes in retinal morphology (transient changes in volume of individual neurons, or thickness of retinal layers). Specifically, comparison between different instrumentations used to acquire ORGs and between results acquired using clinical (human) and experimental (animal) systems will be presented. Additionally, intensity-based and phase-based ORG extraction framework will be presented. Finally, we will discuss our findings in the context of current understanding of measured process, being a result osmotically driven water movements between the photoreceptors, and other retinal neurons and its surroundings.

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ER -

Progress in measurements and interpretation of light-evoked retinal function using OCT based optoretinography (ORG)

Abstract

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ASJC Scopus subject areas

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