Progress in measurements and interpretation of light-evoked retinal function using OCT based optoretinography (ORG)

Robert J. Zawadzki, Pengfei Zhang, Ewelina Pijewska, Denise Valente, Ratheesh K. Meleppat, Kari V. Vienola, Sarah J. Karlen, M. Szkulmowski, John S. Werner, Edward N. Pugh, Ravi S. Jonnal

Research output: Chapter in Book/Report/Conference proceedingConference contribution

Abstract

The development of functional retinal imaging is of great interest to clinical and experimental ophthalmology, because it should provide more sensitive tools for ocular diseases diagnostic that would go beyond current gold standard of simple evaluation of the static retinal morphology. In this presentation we will review our recent progress in measurements and interpretation of OCT-based optoretinograms (ORG) i.e., the paradigm of using NIR OCT to measure in vivo bleaching-induced changes in retinal morphology (transient changes in volume of individual neurons, or thickness of retinal layers). Specifically, comparison between different instrumentations used to acquire ORGs and between results acquired using clinical (human) and experimental (animal) systems will be presented. Additionally, intensity-based and phase-based ORG extraction framework will be presented. Finally, we will discuss our findings in the context of current understanding of measured process, being a result osmotically driven water movements between the photoreceptors, and other retinal neurons and its surroundings.

Original languageEnglish (US)
Title of host publicationOptical Coherence Imaging Techniques and Imaging in Scattering Media IV
EditorsBenjamin J. Vakoc, Maciej Wojtkowski, Yoshiaki Yasuno
PublisherSPIE
ISBN (Electronic)9781510647145
DOIs
StatePublished - 2021
EventOptical Coherence Imaging Techniques and Imaging in Scattering Media IV 2021 - Virtual, Online, Germany
Duration: Jun 20 2021Jun 24 2021

Publication series

NameProgress in Biomedical Optics and Imaging - Proceedings of SPIE
Volume11924
ISSN (Print)1605-7422

Conference

ConferenceOptical Coherence Imaging Techniques and Imaging in Scattering Media IV 2021
Country/TerritoryGermany
CityVirtual, Online
Period6/20/216/24/21

ASJC Scopus subject areas

  • Electronic, Optical and Magnetic Materials
  • Atomic and Molecular Physics, and Optics
  • Biomaterials
  • Radiology Nuclear Medicine and imaging

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