Progress in measurements and interpretation of light-evoked retinal function using OCT-based optoretinography (ORG)

Robert J. Zawadzki, Pengfei Zhang, Ewelina Pijewska, Denise Valente, Ratheesh K. Meleppat, Kari V. Vienola, Sarah J. Karlen, M. Szkulmowski, John S. Werner, Edward N. Pugh, Ravi S. Jonnal

Research output: Chapter in Book/Report/Conference proceedingConference contribution

Abstract

The development of functional retinal imaging is of great interest to clinical and experimental ophthalmology, because it should provide more sensitive tools for ocular diseases diagnostic that would go beyond current gold standard of simple evaluation of the static retinal morphology. In this presentation we will review our recent progress in measurements and interpretation of OCT-based optoretinograms (ORG) i.e., the paradigm of using NIR OCT to measure in vivo bleaching-induced changes in retinal morphology (transient changes in volume of individual neurons, or thickness of retinal layers). Specifically, comparison between different instrumentations used to acquire ORGs and between results acquired using clinical (human) and experimental (animal) systems will be presented. Additionally, intensity-based and phase-based ORG extraction framework will be presented. Finally, we will discuss our findings in the context of current understanding of measured process, being a result osmotically driven water movements between the photoreceptors, and other retinal neurons and its surroundings.

Original languageEnglish (US)
Title of host publicationEuropean Conferences on Biomedical Optics, ECBO 2021
PublisherThe Optical Society
ISBN (Electronic)9781557528209
StatePublished - 2021
Event2021 European Conferences on Biomedical Optics, ECBO 2021 - Virtual, Online, Germany
Duration: Jun 20 2021Jun 24 2021

Publication series

NameOptics InfoBase Conference Papers

Conference

Conference2021 European Conferences on Biomedical Optics, ECBO 2021
Country/TerritoryGermany
CityVirtual, Online
Period6/20/216/24/21

Keywords

  • Functional retinal imaging
  • Light evoked optical signals
  • Optical Coherence Tomography
  • Optophysilogy
  • Optoretinography
  • Water transport, Homeostasis

ASJC Scopus subject areas

  • Electronic, Optical and Magnetic Materials
  • Mechanics of Materials

Fingerprint

Dive into the research topics of 'Progress in measurements and interpretation of light-evoked retinal function using OCT-based optoretinography (ORG)'. Together they form a unique fingerprint.

Cite this