Progress in cerebrovascular disease

Local cerebral blood flow by xenon enhanced CT

D. Gur, S. K. Wolfson, H. Yonas, W. F. Good, L. Shabason, Richard E Latchaw, D. M. Miller, E. E. Cook

Research output: Contribution to journalArticle

64 Citations (Scopus)

Abstract

A noninvasive technique for measuring local cerebral blood flow (LCBF) by xenon enhanced x-ray transmission computed tomography (CT) has been developed and reported quite extensively in recent years. In this method, nonradioactive xenon gas is inhaled and the temporal changes in radiographic enhancement produced by the inhalation are measured by sequential computed tomography. Time dependent xenon concentration within various tissue segments in the brain are used to derive both local partition coefficient (λ) and LCBF. An assessment of this moment reveals that although it provides functional mapping of blood flow with excellent anatomic specificity, there are distinct limitations. The assumptions underlying this methodology are examined and problems associated with various potential applications of this technique are discussed.

Original languageEnglish (US)
Pages (from-to)750-758
Number of pages9
JournalStroke
Volume13
Issue number6
StatePublished - 1982
Externally publishedYes

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Cerebrovascular Circulation
Cerebrovascular Disorders
Xenon
Tomography
X Ray Computed Tomography
Inhalation
Gases
X-Rays
Brain

ASJC Scopus subject areas

  • Cardiology and Cardiovascular Medicine
  • Neuroscience(all)

Cite this

Gur, D., Wolfson, S. K., Yonas, H., Good, W. F., Shabason, L., Latchaw, R. E., ... Cook, E. E. (1982). Progress in cerebrovascular disease: Local cerebral blood flow by xenon enhanced CT. Stroke, 13(6), 750-758.

Progress in cerebrovascular disease : Local cerebral blood flow by xenon enhanced CT. / Gur, D.; Wolfson, S. K.; Yonas, H.; Good, W. F.; Shabason, L.; Latchaw, Richard E; Miller, D. M.; Cook, E. E.

In: Stroke, Vol. 13, No. 6, 1982, p. 750-758.

Research output: Contribution to journalArticle

Gur, D, Wolfson, SK, Yonas, H, Good, WF, Shabason, L, Latchaw, RE, Miller, DM & Cook, EE 1982, 'Progress in cerebrovascular disease: Local cerebral blood flow by xenon enhanced CT', Stroke, vol. 13, no. 6, pp. 750-758.
Gur D, Wolfson SK, Yonas H, Good WF, Shabason L, Latchaw RE et al. Progress in cerebrovascular disease: Local cerebral blood flow by xenon enhanced CT. Stroke. 1982;13(6):750-758.
Gur, D. ; Wolfson, S. K. ; Yonas, H. ; Good, W. F. ; Shabason, L. ; Latchaw, Richard E ; Miller, D. M. ; Cook, E. E. / Progress in cerebrovascular disease : Local cerebral blood flow by xenon enhanced CT. In: Stroke. 1982 ; Vol. 13, No. 6. pp. 750-758.
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