Progress in cerebrovascular disease: Local cerebral blood flow by xenon enhanced CT

D. Gur, S. K. Wolfson, H. Yonas, W. F. Good, L. Shabason, Richard E Latchaw, D. M. Miller, E. E. Cook

Research output: Contribution to journalArticlepeer-review

65 Scopus citations


A noninvasive technique for measuring local cerebral blood flow (LCBF) by xenon enhanced x-ray transmission computed tomography (CT) has been developed and reported quite extensively in recent years. In this method, nonradioactive xenon gas is inhaled and the temporal changes in radiographic enhancement produced by the inhalation are measured by sequential computed tomography. Time dependent xenon concentration within various tissue segments in the brain are used to derive both local partition coefficient (λ) and LCBF. An assessment of this moment reveals that although it provides functional mapping of blood flow with excellent anatomic specificity, there are distinct limitations. The assumptions underlying this methodology are examined and problems associated with various potential applications of this technique are discussed.

Original languageEnglish (US)
Pages (from-to)750-758
Number of pages9
Issue number6
StatePublished - 1982
Externally publishedYes

ASJC Scopus subject areas

  • Cardiology and Cardiovascular Medicine
  • Neuroscience(all)


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