Abstract
The sequential outcome was evaluated for all childhood cancers in which the Pediatric Oncology Group has conducted a series of clinical trials, with constant eligibility, on patients with newly diagnosed cancer. The analysis was applied to more than 7000 patients with cancer diagnosed between 1976 and 1989. These include acute leukemia (4 subgroups), non-Hodgkins lymphoma (4 subgroups), osteogenic sarcoma, and advanced neuroblastoma. In 8 of these 10 disease areas, significant improvement in outcome has occurred. In rare diseases such as pediatric cancer, collaborative studies may be the only way to conduct therapeutic trials of sufficient statistical power. A cooperative group has distinct advantages over a series of ad hoc collaborative studies in that it can maintain a unified data base, study its history with minimal confounding effects of changing institutional participants, and develop long- term research relationships among its participants.
| Original language | English (US) |
|---|---|
| Pages (from-to) | 597-600 |
| Number of pages | 4 |
| Journal | Pediatrics |
| Volume | 89 |
| Issue number | 4 |
| State | Published - 1992 |
| Externally published | Yes |
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Keywords
- cancer
- cooperative group
- neoplasm
ASJC Scopus subject areas
- Pediatrics, Perinatology, and Child Health
Cite this
Progress against childhood cancer : The Pediatric Oncology Group experience. / Vietti, T. J.; Land, V.; Shuster, J. J.; Amylon, M.; Link, M.; Berard, C.; Crist, W.; Borowitz, M.; Falletta, J.; Bowman, W. P.; Brecher, M.; Castleberry, R.; Frankel, L.; Goorin, A.; Hayes, F. A.; Hvizdala, E.; Krischer, J. P.; Pollock, Bradley H; McWilliams, N.
In: Pediatrics, Vol. 89, No. 4, 1992, p. 597-600.Research output: Contribution to journal › Article
}
TY - JOUR
T1 - Progress against childhood cancer
T2 - The Pediatric Oncology Group experience
AU - Vietti, T. J.
AU - Land, V.
AU - Shuster, J. J.
AU - Amylon, M.
AU - Link, M.
AU - Berard, C.
AU - Crist, W.
AU - Borowitz, M.
AU - Falletta, J.
AU - Bowman, W. P.
AU - Brecher, M.
AU - Castleberry, R.
AU - Frankel, L.
AU - Goorin, A.
AU - Hayes, F. A.
AU - Hvizdala, E.
AU - Krischer, J. P.
AU - Pollock, Bradley H
AU - McWilliams, N.
PY - 1992
Y1 - 1992
N2 - The sequential outcome was evaluated for all childhood cancers in which the Pediatric Oncology Group has conducted a series of clinical trials, with constant eligibility, on patients with newly diagnosed cancer. The analysis was applied to more than 7000 patients with cancer diagnosed between 1976 and 1989. These include acute leukemia (4 subgroups), non-Hodgkins lymphoma (4 subgroups), osteogenic sarcoma, and advanced neuroblastoma. In 8 of these 10 disease areas, significant improvement in outcome has occurred. In rare diseases such as pediatric cancer, collaborative studies may be the only way to conduct therapeutic trials of sufficient statistical power. A cooperative group has distinct advantages over a series of ad hoc collaborative studies in that it can maintain a unified data base, study its history with minimal confounding effects of changing institutional participants, and develop long- term research relationships among its participants.
AB - The sequential outcome was evaluated for all childhood cancers in which the Pediatric Oncology Group has conducted a series of clinical trials, with constant eligibility, on patients with newly diagnosed cancer. The analysis was applied to more than 7000 patients with cancer diagnosed between 1976 and 1989. These include acute leukemia (4 subgroups), non-Hodgkins lymphoma (4 subgroups), osteogenic sarcoma, and advanced neuroblastoma. In 8 of these 10 disease areas, significant improvement in outcome has occurred. In rare diseases such as pediatric cancer, collaborative studies may be the only way to conduct therapeutic trials of sufficient statistical power. A cooperative group has distinct advantages over a series of ad hoc collaborative studies in that it can maintain a unified data base, study its history with minimal confounding effects of changing institutional participants, and develop long- term research relationships among its participants.
KW - cancer
KW - cooperative group
KW - neoplasm
UR - http://www.scopus.com/inward/record.url?scp=0026588052&partnerID=8YFLogxK
UR - http://www.scopus.com/inward/citedby.url?scp=0026588052&partnerID=8YFLogxK
M3 - Article
C2 - 1557237
AN - SCOPUS:0026588052
VL - 89
SP - 597
EP - 600
JO - Pediatrics
JF - Pediatrics
SN - 0031-4005
IS - 4
ER -