Prognostic value of the galactose test in predicting survival of patients with cirrhosis evaluated for liver transplantation. A prospective multicenter Italian study

Francesco Salerno, Gianmario Borroni, Pamela Moser, Angelo Sangiovanni, Piero Almasio, Gabriele Budillon, Gaetano Capuano, Maurizio Muraca, Giulio Marchesini, Mauro Bernardi, Giorgio Marenco, Gianpaolo Molino, Lorenzo Rossaro, Antonio Solinas, Antonio Ascione, Luca Carpinelli, Flavia Politi, Giovanni Giuseppe Di Costanzo, Lucia Boselli, Franco TrevisaniAndrea Fabbri, Claudia Sama, Antonio Giudici, Irene Ponassi, Angelo Di Napoli, Paolo Avagnina, Anna Grazia Niro, Angelo Deplano, Luca Fabris, Rosa Maria Iemmolo, Gerald Eko, Mario Slavagnini

Research output: Contribution to journalArticlepeer-review

45 Scopus citations

Abstract

Aims/Methods: The present study aimed to examine whether the galactose elimination capacity can be used to predict the survival of patients with advanced liver disease. We studied 194 patients with cirrhosis, belonging to Child class B and C, for 2 years each. Results: The overall probability of survival was 79% at 6 months, 72% at 1 year and 62% at 2 years. Variables significantly associated with the duration of survival, as assessed by univariate analysis, were the Child-Pugh score, presence of ascites, size of esophageal varices, prothrombin time, albumin, bilirubin, urea, creatinine, glucose and galactose elimination capacity. By a multivariable analysis, only Pugh score (p = 0.005), creatinine (p < 0.001), varices (p = 0.001) and galactose elimination capacity (p < 0.001) were independent predictors of mortality. The galactose elimination capacity was even more sensitive when the endpoint was limited to deaths due to liver failure and hepatorenal syndrome. A new score obtained by summing the Pugh score with a score derived from galactose elimination capacity was quite simple and accurate for predicting survival. Conclusions: The quantitative measurement of liver function as the galactose elimination capacity could be of use to identify patients with cirrhosis and probable short survival who might benefit most from urgent transplantation.

Original languageEnglish (US)
Pages (from-to)474-480
Number of pages7
JournalJournal of Hepatology
Volume25
Issue number4
DOIs
StatePublished - Oct 1996
Externally publishedYes

Keywords

  • Child-Pugh score
  • Galactose
  • Liver transplantation
  • Survival

ASJC Scopus subject areas

  • Gastroenterology

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