Prognostic value of the galactose test in predicting survival of patients with cirrhosis evaluated for liver transplantation. A prospective multicenter Italian study

Francesco Salerno, Gianmario Borroni, Pamela Moser, Angelo Sangiovanni, Piero Almasio, Gabriele Budillon, Gaetano Capuano, Maurizio Muraca, Giulio Marchesini, Mauro Bernardi, Giorgio Marenco, Gianpaolo Molino, Lorenzo Rossaro, Antonio Solinas, Antonio Ascione, Luca Carpinelli, Flavia Politi, Giovanni Giuseppe Di Costanzo, Lucia Boselli, Franco Trevisani & 12 others Andrea Fabbri, Claudia Sama, Antonio Giudici, Irene Ponassi, Angelo Di Napoli, Paolo Avagnina, Anna Grazia Niro, Angelo Deplano, Luca Fabris, Rosa Maria Iemmolo, Gerald Eko, Mario Slavagnini

Research output: Contribution to journalArticle

44 Citations (Scopus)

Abstract

Aims/Methods: The present study aimed to examine whether the galactose elimination capacity can be used to predict the survival of patients with advanced liver disease. We studied 194 patients with cirrhosis, belonging to Child class B and C, for 2 years each. Results: The overall probability of survival was 79% at 6 months, 72% at 1 year and 62% at 2 years. Variables significantly associated with the duration of survival, as assessed by univariate analysis, were the Child-Pugh score, presence of ascites, size of esophageal varices, prothrombin time, albumin, bilirubin, urea, creatinine, glucose and galactose elimination capacity. By a multivariable analysis, only Pugh score (p = 0.005), creatinine (p < 0.001), varices (p = 0.001) and galactose elimination capacity (p < 0.001) were independent predictors of mortality. The galactose elimination capacity was even more sensitive when the endpoint was limited to deaths due to liver failure and hepatorenal syndrome. A new score obtained by summing the Pugh score with a score derived from galactose elimination capacity was quite simple and accurate for predicting survival. Conclusions: The quantitative measurement of liver function as the galactose elimination capacity could be of use to identify patients with cirrhosis and probable short survival who might benefit most from urgent transplantation.

Original languageEnglish (US)
Pages (from-to)474-480
Number of pages7
JournalJournal of Hepatology
Volume25
Issue number4
DOIs
StatePublished - Oct 1996
Externally publishedYes

Fingerprint

Galactose
Liver Transplantation
Multicenter Studies
Fibrosis
Survival
Creatinine
Hepatorenal Syndrome
Esophageal and Gastric Varices
Prothrombin Time
Liver Failure
Varicose Veins
Bilirubin
Ascites
Urea
Liver Diseases
Albumins
Transplantation
Glucose
Mortality
Liver

Keywords

  • Child-Pugh score
  • Galactose
  • Liver transplantation
  • Survival

ASJC Scopus subject areas

  • Gastroenterology

Cite this

Prognostic value of the galactose test in predicting survival of patients with cirrhosis evaluated for liver transplantation. A prospective multicenter Italian study. / Salerno, Francesco; Borroni, Gianmario; Moser, Pamela; Sangiovanni, Angelo; Almasio, Piero; Budillon, Gabriele; Capuano, Gaetano; Muraca, Maurizio; Marchesini, Giulio; Bernardi, Mauro; Marenco, Giorgio; Molino, Gianpaolo; Rossaro, Lorenzo; Solinas, Antonio; Ascione, Antonio; Carpinelli, Luca; Politi, Flavia; Di Costanzo, Giovanni Giuseppe; Boselli, Lucia; Trevisani, Franco; Fabbri, Andrea; Sama, Claudia; Giudici, Antonio; Ponassi, Irene; Di Napoli, Angelo; Avagnina, Paolo; Niro, Anna Grazia; Deplano, Angelo; Fabris, Luca; Iemmolo, Rosa Maria; Eko, Gerald; Slavagnini, Mario.

In: Journal of Hepatology, Vol. 25, No. 4, 10.1996, p. 474-480.

Research output: Contribution to journalArticle

Salerno, F, Borroni, G, Moser, P, Sangiovanni, A, Almasio, P, Budillon, G, Capuano, G, Muraca, M, Marchesini, G, Bernardi, M, Marenco, G, Molino, G, Rossaro, L, Solinas, A, Ascione, A, Carpinelli, L, Politi, F, Di Costanzo, GG, Boselli, L, Trevisani, F, Fabbri, A, Sama, C, Giudici, A, Ponassi, I, Di Napoli, A, Avagnina, P, Niro, AG, Deplano, A, Fabris, L, Iemmolo, RM, Eko, G & Slavagnini, M 1996, 'Prognostic value of the galactose test in predicting survival of patients with cirrhosis evaluated for liver transplantation. A prospective multicenter Italian study', Journal of Hepatology, vol. 25, no. 4, pp. 474-480. https://doi.org/10.1016/S0168-8278(96)80206-6
Salerno, Francesco ; Borroni, Gianmario ; Moser, Pamela ; Sangiovanni, Angelo ; Almasio, Piero ; Budillon, Gabriele ; Capuano, Gaetano ; Muraca, Maurizio ; Marchesini, Giulio ; Bernardi, Mauro ; Marenco, Giorgio ; Molino, Gianpaolo ; Rossaro, Lorenzo ; Solinas, Antonio ; Ascione, Antonio ; Carpinelli, Luca ; Politi, Flavia ; Di Costanzo, Giovanni Giuseppe ; Boselli, Lucia ; Trevisani, Franco ; Fabbri, Andrea ; Sama, Claudia ; Giudici, Antonio ; Ponassi, Irene ; Di Napoli, Angelo ; Avagnina, Paolo ; Niro, Anna Grazia ; Deplano, Angelo ; Fabris, Luca ; Iemmolo, Rosa Maria ; Eko, Gerald ; Slavagnini, Mario. / Prognostic value of the galactose test in predicting survival of patients with cirrhosis evaluated for liver transplantation. A prospective multicenter Italian study. In: Journal of Hepatology. 1996 ; Vol. 25, No. 4. pp. 474-480.
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abstract = "Aims/Methods: The present study aimed to examine whether the galactose elimination capacity can be used to predict the survival of patients with advanced liver disease. We studied 194 patients with cirrhosis, belonging to Child class B and C, for 2 years each. Results: The overall probability of survival was 79{\%} at 6 months, 72{\%} at 1 year and 62{\%} at 2 years. Variables significantly associated with the duration of survival, as assessed by univariate analysis, were the Child-Pugh score, presence of ascites, size of esophageal varices, prothrombin time, albumin, bilirubin, urea, creatinine, glucose and galactose elimination capacity. By a multivariable analysis, only Pugh score (p = 0.005), creatinine (p < 0.001), varices (p = 0.001) and galactose elimination capacity (p < 0.001) were independent predictors of mortality. The galactose elimination capacity was even more sensitive when the endpoint was limited to deaths due to liver failure and hepatorenal syndrome. A new score obtained by summing the Pugh score with a score derived from galactose elimination capacity was quite simple and accurate for predicting survival. Conclusions: The quantitative measurement of liver function as the galactose elimination capacity could be of use to identify patients with cirrhosis and probable short survival who might benefit most from urgent transplantation.",
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T1 - Prognostic value of the galactose test in predicting survival of patients with cirrhosis evaluated for liver transplantation. A prospective multicenter Italian study

AU - Salerno, Francesco

AU - Borroni, Gianmario

AU - Moser, Pamela

AU - Sangiovanni, Angelo

AU - Almasio, Piero

AU - Budillon, Gabriele

AU - Capuano, Gaetano

AU - Muraca, Maurizio

AU - Marchesini, Giulio

AU - Bernardi, Mauro

AU - Marenco, Giorgio

AU - Molino, Gianpaolo

AU - Rossaro, Lorenzo

AU - Solinas, Antonio

AU - Ascione, Antonio

AU - Carpinelli, Luca

AU - Politi, Flavia

AU - Di Costanzo, Giovanni Giuseppe

AU - Boselli, Lucia

AU - Trevisani, Franco

AU - Fabbri, Andrea

AU - Sama, Claudia

AU - Giudici, Antonio

AU - Ponassi, Irene

AU - Di Napoli, Angelo

AU - Avagnina, Paolo

AU - Niro, Anna Grazia

AU - Deplano, Angelo

AU - Fabris, Luca

AU - Iemmolo, Rosa Maria

AU - Eko, Gerald

AU - Slavagnini, Mario

PY - 1996/10

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N2 - Aims/Methods: The present study aimed to examine whether the galactose elimination capacity can be used to predict the survival of patients with advanced liver disease. We studied 194 patients with cirrhosis, belonging to Child class B and C, for 2 years each. Results: The overall probability of survival was 79% at 6 months, 72% at 1 year and 62% at 2 years. Variables significantly associated with the duration of survival, as assessed by univariate analysis, were the Child-Pugh score, presence of ascites, size of esophageal varices, prothrombin time, albumin, bilirubin, urea, creatinine, glucose and galactose elimination capacity. By a multivariable analysis, only Pugh score (p = 0.005), creatinine (p < 0.001), varices (p = 0.001) and galactose elimination capacity (p < 0.001) were independent predictors of mortality. The galactose elimination capacity was even more sensitive when the endpoint was limited to deaths due to liver failure and hepatorenal syndrome. A new score obtained by summing the Pugh score with a score derived from galactose elimination capacity was quite simple and accurate for predicting survival. Conclusions: The quantitative measurement of liver function as the galactose elimination capacity could be of use to identify patients with cirrhosis and probable short survival who might benefit most from urgent transplantation.

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KW - Galactose

KW - Liver transplantation

KW - Survival

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