Prognostic factors associated with radiotherapy of squamous cell carcinoma of the nasal plane in cats.

Alain P Theon, B. R. Madewell, V. I. Shearn, J. E. Moulton

Research output: Contribution to journalArticle

67 Citations (Scopus)

Abstract

Ninety cats were irradiated for treatment of squamous cell carcinoma of the nasal plane. The 1- and 5-year progression-free survival rates were 60.1 +/- 5.5% and 10.3 +/- 6.2%, respectively. Analysis of progression-free survival times revealed that clinical stage and tumor proliferative fraction (estimated by the use of a proliferating cell nuclear-antigen immunohistochemical method) had significant prognostic value. Conversely, coat color, presence of multiple facial carcinomas, histologic grade, and feline immunodeficiency virus infection status were not found to have prognostic value. Acute radiation reactions were mild and self-limiting. Severe chronic radiation reactions were more frequent in cats infected with feline immunodeficiency virus. Results of the study indicated that cats with squamous cell carcinoma of the nasal plane benefit from radiotherapy and that treatment might be improved by increasing the radiation dose as well as altering the dose-fractionation scheme.

Original languageEnglish (US)
Pages (from-to)991-996
Number of pages6
JournalJournal of the American Veterinary Medical Association
Volume206
Issue number7
StatePublished - Apr 1 1995

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squamous cell carcinoma
radiotherapy
Nose
Feline Immunodeficiency Virus
Squamous Cell Carcinoma
Feline immunodeficiency virus
Cats
Radiotherapy
cats
Radiation
Disease-Free Survival
Dose Fractionation
proliferating cell nuclear antigen
Proliferating Cell Nuclear Antigen
Virus Diseases
dosage
carcinoma
fractionation
Color
survival rate

ASJC Scopus subject areas

  • veterinary(all)

Cite this

Prognostic factors associated with radiotherapy of squamous cell carcinoma of the nasal plane in cats. / Theon, Alain P; Madewell, B. R.; Shearn, V. I.; Moulton, J. E.

In: Journal of the American Veterinary Medical Association, Vol. 206, No. 7, 01.04.1995, p. 991-996.

Research output: Contribution to journalArticle

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