Proflavin mutagenesis of bacteria

Tadahiko Kohno, John R. Roth

Research output: Contribution to journalArticlepeer-review

25 Scopus citations


Once a permeability barrier is overcome, proflavin is highly mutagenic for Salmonella typhimurium and Escherichia coli. Mutagenesis of the his operon (in Salmonella) and lac operon (in E. coli) depends on derepression of the respective operons. No proflavin mutagenesis was detected in rec- strains. Over 100 proflavin-induced his mutants have been classified: 50% are base substitution types, 30% are stable (10% demonstrably multisite), and only 20% are probably frameshift mutations. None of the proflavin-induced frameshift mutations is of the type previously shown to be suppressed by frameshift suppressor mutations.

Original languageEnglish (US)
JournalJournal of Molecular Biology
Issue number1
StatePublished - Oct 15 1974

ASJC Scopus subject areas

  • Virology


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