Profile and predictors of normal ganglion cell-inner plexiform layer thickness measured with frequency-domain optical coherence tomography

Jean Claude Mwanza, Mary K. Durbin, Donald L. Budenz, Christopher A. Girkin, Christopher K. Leung, Jeffrey M. Liebmann, James H. Peace, John S Werner, Gadi Wollstein

Research output: Contribution to journalArticle

144 Citations (Scopus)

Abstract

Purpose. To describe the profile and identify the predictors of the ganglion cell-inner plexiform layer (GCIPL) thickness measured with frequency-domain optical coherence tomography (FD-OCT) in normal eyes. Methods. Two hundred eighty-two normal subjects underwent macular and optic disc scanning in both eyes with Cirrus high-definition (HD)-OCT (Carl Zeiss Meditec, Dublin, CA). Linear regression analyses were performed to determine the association between GCIPL thickness and age, sex, ethnicity (Europeans, Africans, Hispanics, Asians, and Indians), eye laterality, refraction, intraocular pressure, axial length, central corneal thickness, mean retinal nerve fiber layer (RNFL) thickness, disc and rim areas, cup-to-disc area, vertical and horizontal cup-to-disc diameter ratios, vertical rim thickness, and OCT signal strength. Results. The mean (±SD) age was 46.2 ± 16.9 years (range, 18-84 years). The mean and minimum GCIPL thicknesses (±SD) were 82.1 ± 6.2 and 80.4 ± 6.4;xm, respectively. There were significant differences in GCIPL thickness between macular sectors (P < 0.05), except between the superotemporal and inferonasal sectors (P = 0.63). The superonasal sector had the thickest and the inferior had the thinnest GCIPL. The GCIPL of the superior hemisphere was thicker than that of the inferior, and the nasal sector GCIPL was significantly thicker than the temporal one (P < 0.001). The average GCIPL did not differ between male and female subjects (P = 0.16) after adjustment for axial length and between ethnic groups (P = 0.41) after adjustment for age, axial length, and RNFL thickness. Significant predictors of mean GCIPL thickness were average RNFL thickness (β = 0.37, P < 0.001), age (β = -0.083, P < 0.001), axial length (β = -0.87, P = 0.001), and male sex (β = -1.62, P = 0.005). Conclusions. The independent factors associated with thinner GCIPL include thinner RNFL, older age, longer ocular axial length, and being male. Although the magnitude of the effect of age, axial length, and sex are small, these factors should be taken into account when interpreting Cirrus HD-OCT-based GCIPL thickness measurements.

Original languageEnglish (US)
Pages (from-to)7872-7879
Number of pages8
JournalInvestigative Ophthalmology and Visual Science
Volume52
Issue number11
DOIs
StatePublished - Oct 2011

Fingerprint

Optical Coherence Tomography
Ganglia
Nerve Fibers
Eye Axial Length
Sex Factors
Optic Disk
Intraocular Pressure
Nose
Hispanic Americans
Ethnic Groups
Linear Models
Regression Analysis

ASJC Scopus subject areas

  • Ophthalmology
  • Sensory Systems
  • Cellular and Molecular Neuroscience

Cite this

Profile and predictors of normal ganglion cell-inner plexiform layer thickness measured with frequency-domain optical coherence tomography. / Mwanza, Jean Claude; Durbin, Mary K.; Budenz, Donald L.; Girkin, Christopher A.; Leung, Christopher K.; Liebmann, Jeffrey M.; Peace, James H.; Werner, John S; Wollstein, Gadi.

In: Investigative Ophthalmology and Visual Science, Vol. 52, No. 11, 10.2011, p. 7872-7879.

Research output: Contribution to journalArticle

Mwanza, Jean Claude ; Durbin, Mary K. ; Budenz, Donald L. ; Girkin, Christopher A. ; Leung, Christopher K. ; Liebmann, Jeffrey M. ; Peace, James H. ; Werner, John S ; Wollstein, Gadi. / Profile and predictors of normal ganglion cell-inner plexiform layer thickness measured with frequency-domain optical coherence tomography. In: Investigative Ophthalmology and Visual Science. 2011 ; Vol. 52, No. 11. pp. 7872-7879.
@article{4f137c936ac54ef3b40af53a6a7adad7,
title = "Profile and predictors of normal ganglion cell-inner plexiform layer thickness measured with frequency-domain optical coherence tomography",
abstract = "Purpose. To describe the profile and identify the predictors of the ganglion cell-inner plexiform layer (GCIPL) thickness measured with frequency-domain optical coherence tomography (FD-OCT) in normal eyes. Methods. Two hundred eighty-two normal subjects underwent macular and optic disc scanning in both eyes with Cirrus high-definition (HD)-OCT (Carl Zeiss Meditec, Dublin, CA). Linear regression analyses were performed to determine the association between GCIPL thickness and age, sex, ethnicity (Europeans, Africans, Hispanics, Asians, and Indians), eye laterality, refraction, intraocular pressure, axial length, central corneal thickness, mean retinal nerve fiber layer (RNFL) thickness, disc and rim areas, cup-to-disc area, vertical and horizontal cup-to-disc diameter ratios, vertical rim thickness, and OCT signal strength. Results. The mean (±SD) age was 46.2 ± 16.9 years (range, 18-84 years). The mean and minimum GCIPL thicknesses (±SD) were 82.1 ± 6.2 and 80.4 ± 6.4;xm, respectively. There were significant differences in GCIPL thickness between macular sectors (P < 0.05), except between the superotemporal and inferonasal sectors (P = 0.63). The superonasal sector had the thickest and the inferior had the thinnest GCIPL. The GCIPL of the superior hemisphere was thicker than that of the inferior, and the nasal sector GCIPL was significantly thicker than the temporal one (P < 0.001). The average GCIPL did not differ between male and female subjects (P = 0.16) after adjustment for axial length and between ethnic groups (P = 0.41) after adjustment for age, axial length, and RNFL thickness. Significant predictors of mean GCIPL thickness were average RNFL thickness (β = 0.37, P < 0.001), age (β = -0.083, P < 0.001), axial length (β = -0.87, P = 0.001), and male sex (β = -1.62, P = 0.005). Conclusions. The independent factors associated with thinner GCIPL include thinner RNFL, older age, longer ocular axial length, and being male. Although the magnitude of the effect of age, axial length, and sex are small, these factors should be taken into account when interpreting Cirrus HD-OCT-based GCIPL thickness measurements.",
author = "Mwanza, {Jean Claude} and Durbin, {Mary K.} and Budenz, {Donald L.} and Girkin, {Christopher A.} and Leung, {Christopher K.} and Liebmann, {Jeffrey M.} and Peace, {James H.} and Werner, {John S} and Gadi Wollstein",
year = "2011",
month = "10",
doi = "10.1167/iovs.11-7896",
language = "English (US)",
volume = "52",
pages = "7872--7879",
journal = "Investigative Ophthalmology and Visual Science",
issn = "0146-0404",
publisher = "Association for Research in Vision and Ophthalmology Inc.",
number = "11",

}

TY - JOUR

T1 - Profile and predictors of normal ganglion cell-inner plexiform layer thickness measured with frequency-domain optical coherence tomography

AU - Mwanza, Jean Claude

AU - Durbin, Mary K.

AU - Budenz, Donald L.

AU - Girkin, Christopher A.

AU - Leung, Christopher K.

AU - Liebmann, Jeffrey M.

AU - Peace, James H.

AU - Werner, John S

AU - Wollstein, Gadi

PY - 2011/10

Y1 - 2011/10

N2 - Purpose. To describe the profile and identify the predictors of the ganglion cell-inner plexiform layer (GCIPL) thickness measured with frequency-domain optical coherence tomography (FD-OCT) in normal eyes. Methods. Two hundred eighty-two normal subjects underwent macular and optic disc scanning in both eyes with Cirrus high-definition (HD)-OCT (Carl Zeiss Meditec, Dublin, CA). Linear regression analyses were performed to determine the association between GCIPL thickness and age, sex, ethnicity (Europeans, Africans, Hispanics, Asians, and Indians), eye laterality, refraction, intraocular pressure, axial length, central corneal thickness, mean retinal nerve fiber layer (RNFL) thickness, disc and rim areas, cup-to-disc area, vertical and horizontal cup-to-disc diameter ratios, vertical rim thickness, and OCT signal strength. Results. The mean (±SD) age was 46.2 ± 16.9 years (range, 18-84 years). The mean and minimum GCIPL thicknesses (±SD) were 82.1 ± 6.2 and 80.4 ± 6.4;xm, respectively. There were significant differences in GCIPL thickness between macular sectors (P < 0.05), except between the superotemporal and inferonasal sectors (P = 0.63). The superonasal sector had the thickest and the inferior had the thinnest GCIPL. The GCIPL of the superior hemisphere was thicker than that of the inferior, and the nasal sector GCIPL was significantly thicker than the temporal one (P < 0.001). The average GCIPL did not differ between male and female subjects (P = 0.16) after adjustment for axial length and between ethnic groups (P = 0.41) after adjustment for age, axial length, and RNFL thickness. Significant predictors of mean GCIPL thickness were average RNFL thickness (β = 0.37, P < 0.001), age (β = -0.083, P < 0.001), axial length (β = -0.87, P = 0.001), and male sex (β = -1.62, P = 0.005). Conclusions. The independent factors associated with thinner GCIPL include thinner RNFL, older age, longer ocular axial length, and being male. Although the magnitude of the effect of age, axial length, and sex are small, these factors should be taken into account when interpreting Cirrus HD-OCT-based GCIPL thickness measurements.

AB - Purpose. To describe the profile and identify the predictors of the ganglion cell-inner plexiform layer (GCIPL) thickness measured with frequency-domain optical coherence tomography (FD-OCT) in normal eyes. Methods. Two hundred eighty-two normal subjects underwent macular and optic disc scanning in both eyes with Cirrus high-definition (HD)-OCT (Carl Zeiss Meditec, Dublin, CA). Linear regression analyses were performed to determine the association between GCIPL thickness and age, sex, ethnicity (Europeans, Africans, Hispanics, Asians, and Indians), eye laterality, refraction, intraocular pressure, axial length, central corneal thickness, mean retinal nerve fiber layer (RNFL) thickness, disc and rim areas, cup-to-disc area, vertical and horizontal cup-to-disc diameter ratios, vertical rim thickness, and OCT signal strength. Results. The mean (±SD) age was 46.2 ± 16.9 years (range, 18-84 years). The mean and minimum GCIPL thicknesses (±SD) were 82.1 ± 6.2 and 80.4 ± 6.4;xm, respectively. There were significant differences in GCIPL thickness between macular sectors (P < 0.05), except between the superotemporal and inferonasal sectors (P = 0.63). The superonasal sector had the thickest and the inferior had the thinnest GCIPL. The GCIPL of the superior hemisphere was thicker than that of the inferior, and the nasal sector GCIPL was significantly thicker than the temporal one (P < 0.001). The average GCIPL did not differ between male and female subjects (P = 0.16) after adjustment for axial length and between ethnic groups (P = 0.41) after adjustment for age, axial length, and RNFL thickness. Significant predictors of mean GCIPL thickness were average RNFL thickness (β = 0.37, P < 0.001), age (β = -0.083, P < 0.001), axial length (β = -0.87, P = 0.001), and male sex (β = -1.62, P = 0.005). Conclusions. The independent factors associated with thinner GCIPL include thinner RNFL, older age, longer ocular axial length, and being male. Although the magnitude of the effect of age, axial length, and sex are small, these factors should be taken into account when interpreting Cirrus HD-OCT-based GCIPL thickness measurements.

UR - http://www.scopus.com/inward/record.url?scp=80053625749&partnerID=8YFLogxK

UR - http://www.scopus.com/inward/citedby.url?scp=80053625749&partnerID=8YFLogxK

U2 - 10.1167/iovs.11-7896

DO - 10.1167/iovs.11-7896

M3 - Article

C2 - 21873658

AN - SCOPUS:80053625749

VL - 52

SP - 7872

EP - 7879

JO - Investigative Ophthalmology and Visual Science

JF - Investigative Ophthalmology and Visual Science

SN - 0146-0404

IS - 11

ER -