Abstract
Culture of Schwann cells and endoneurial fibroblasts from newborn rat sciatic nerves in the presence of supernatants obtained from concanavalin A (Con-A)-stimulated rat mononuclear cells resulted in proliferation of both cell types. Con-A did not induce Schwann cell or fibroblast proliferation. Supernatant from a Gibbon T-cell lymphoma and chromatographically purified rat interleukin-2 (IL-2) induced fibroblast but not Schwann cell proliferation, and cloned human IL-2 did not induce proliferation of either cell type. Proliferation of Schwann cells and endoneurial fibroblasts induced by activated mononuclear inflammatory cells may be important in inflammatory demyelinative neuropathies.
Original language | English (US) |
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Pages (from-to) | 105-111 |
Number of pages | 7 |
Journal | Neuroscience Letters |
Volume | 57 |
Issue number | 2 |
DOIs | |
State | Published - Jun 12 1985 |
Externally published | Yes |
Keywords
- fibroblast
- interleukin-2
- lymphokine
- monokine
- neuropathy
- Schwann cell
ASJC Scopus subject areas
- Neuroscience(all)