Products of activated lymphocytes stimulate Schwann cell mitosis in vitro

Robert P. Lisak, Gen Sobue, Diana Kuchmy, James B. Burns, David E Pleasure

Research output: Contribution to journalArticlepeer-review

10 Scopus citations

Abstract

Culture of Schwann cells and endoneurial fibroblasts from newborn rat sciatic nerves in the presence of supernatants obtained from concanavalin A (Con-A)-stimulated rat mononuclear cells resulted in proliferation of both cell types. Con-A did not induce Schwann cell or fibroblast proliferation. Supernatant from a Gibbon T-cell lymphoma and chromatographically purified rat interleukin-2 (IL-2) induced fibroblast but not Schwann cell proliferation, and cloned human IL-2 did not induce proliferation of either cell type. Proliferation of Schwann cells and endoneurial fibroblasts induced by activated mononuclear inflammatory cells may be important in inflammatory demyelinative neuropathies.

Original languageEnglish (US)
Pages (from-to)105-111
Number of pages7
JournalNeuroscience Letters
Volume57
Issue number2
DOIs
StatePublished - Jun 12 1985
Externally publishedYes

Keywords

  • fibroblast
  • interleukin-2
  • lymphokine
  • monokine
  • neuropathy
  • Schwann cell

ASJC Scopus subject areas

  • Neuroscience(all)

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