Production of periodic arrays of protein nanostructures using particle lithography

Jayne C. Garno, Nabil A. Amro, Kapila Wadu-Mesthrige, Gang-yu Liu

Research output: Contribution to journalArticle

65 Scopus citations

Abstract

We introduce a new method of nanoparticle lithography to produce periodic arrays of protein nanostructures. The resulting protein arrays are characterized using atomic force microscopy. The periodicity and detailed morphology of these arrays can be varied by selecting latex particles with a desired size and the protein-to-latex ratio. Particle lithography offers the advantages of nanometer precision and high throughput. The proteins within the nanostructures retain the ability to bind corresponding specific antibodies. This approach provides an alternative means for production of a new generation of nanostructure-based biochips and sensors.

Original languageEnglish (US)
Pages (from-to)8186-8192
Number of pages7
JournalLangmuir
Volume18
Issue number21
DOIs
StatePublished - Oct 15 2002

ASJC Scopus subject areas

  • Colloid and Surface Chemistry
  • Physical and Theoretical Chemistry

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