Abstract
Rabbit hind limbs were subjected to 5 hours of ischemia with or without 1 hour of in vivo reperfusion, and the response of femoral artery segments to vasocontrictors and vasodilators was studied in vitro. The ability of endothelium-derived relaxing factor (EDRF)-dependent vasodilators to relax arterial segments was not altered after up to 5 hours of ischemia alone but was significantly decreased after 4 hours of ischemia if followed by 1 hour of in vitro reperfusion. Thus, we concluded that a specific injury occurs to endothelial cells after ischemia-reperfusion, which occurs solely during the reperfusion period.
| Original language | English (US) |
|---|---|
| Pages (from-to) | 216-220 |
| Number of pages | 5 |
| Journal | The American Journal of Surgery |
| Volume | 166 |
| Issue number | 2 |
| DOIs | |
| State | Published - 1993 |
| Externally published | Yes |
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ASJC Scopus subject areas
- Surgery
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Production of endothelium-derived relaxing factor (EDRF) is compromised after ischemia and reperfusion. / Summers, Stephen T.; Zinner, Michael J.; Freischlag, Julie A.
In: The American Journal of Surgery, Vol. 166, No. 2, 1993, p. 216-220.Research output: Contribution to journal › Article
}
TY - JOUR
T1 - Production of endothelium-derived relaxing factor (EDRF) is compromised after ischemia and reperfusion
AU - Summers, Stephen T.
AU - Zinner, Michael J.
AU - Freischlag, Julie A.
PY - 1993
Y1 - 1993
N2 - Rabbit hind limbs were subjected to 5 hours of ischemia with or without 1 hour of in vivo reperfusion, and the response of femoral artery segments to vasocontrictors and vasodilators was studied in vitro. The ability of endothelium-derived relaxing factor (EDRF)-dependent vasodilators to relax arterial segments was not altered after up to 5 hours of ischemia alone but was significantly decreased after 4 hours of ischemia if followed by 1 hour of in vitro reperfusion. Thus, we concluded that a specific injury occurs to endothelial cells after ischemia-reperfusion, which occurs solely during the reperfusion period.
AB - Rabbit hind limbs were subjected to 5 hours of ischemia with or without 1 hour of in vivo reperfusion, and the response of femoral artery segments to vasocontrictors and vasodilators was studied in vitro. The ability of endothelium-derived relaxing factor (EDRF)-dependent vasodilators to relax arterial segments was not altered after up to 5 hours of ischemia alone but was significantly decreased after 4 hours of ischemia if followed by 1 hour of in vitro reperfusion. Thus, we concluded that a specific injury occurs to endothelial cells after ischemia-reperfusion, which occurs solely during the reperfusion period.
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UR - http://www.scopus.com/inward/citedby.url?scp=0027257496&partnerID=8YFLogxK
U2 - 10.1016/S0002-9610(05)81059-1
DO - 10.1016/S0002-9610(05)81059-1
M3 - Article
VL - 166
SP - 216
EP - 220
JO - American Journal of Surgery
JF - American Journal of Surgery
SN - 0002-9610
IS - 2
ER -