Abstract
Rabbit hind limbs were subjected to 5 hours of ischemia with or without 1 hour of in vivo reperfusion, and the response of femoral artery segments to vasocontrictors and vasodilators was studied in vitro. The ability of endothelium-derived relaxing factor (EDRF)-dependent vasodilators to relax arterial segments was not altered after up to 5 hours of ischemia alone but was significantly decreased after 4 hours of ischemia if followed by 1 hour of in vitro reperfusion. Thus, we concluded that a specific injury occurs to endothelial cells after ischemia-reperfusion, which occurs solely during the reperfusion period.
| Original language | English (US) |
|---|---|
| Pages (from-to) | 216-220 |
| Number of pages | 5 |
| Journal | The American Journal of Surgery |
| Volume | 166 |
| Issue number | 2 |
| DOIs | |
| State | Published - 1993 |
| Externally published | Yes |
ASJC Scopus subject areas
- Surgery
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Summers, S. T., Zinner, M. J., & Freischlag, J. A. (1993). Production of endothelium-derived relaxing factor (EDRF) is compromised after ischemia and reperfusion. The American Journal of Surgery, 166(2), 216-220. https://doi.org/10.1016/S0002-9610(05)81059-1