Production of endothelium-derived relaxing factor (EDRF) is compromised after ischemia and reperfusion

Stephen T. Summers, Michael J. Zinner, Julie A. Freischlag

Research output: Contribution to journalArticle

27 Scopus citations

Abstract

Rabbit hind limbs were subjected to 5 hours of ischemia with or without 1 hour of in vivo reperfusion, and the response of femoral artery segments to vasocontrictors and vasodilators was studied in vitro. The ability of endothelium-derived relaxing factor (EDRF)-dependent vasodilators to relax arterial segments was not altered after up to 5 hours of ischemia alone but was significantly decreased after 4 hours of ischemia if followed by 1 hour of in vitro reperfusion. Thus, we concluded that a specific injury occurs to endothelial cells after ischemia-reperfusion, which occurs solely during the reperfusion period.

Original languageEnglish (US)
Pages (from-to)216-220
Number of pages5
JournalThe American Journal of Surgery
Volume166
Issue number2
DOIs
StatePublished - 1993
Externally publishedYes

ASJC Scopus subject areas

  • Surgery

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