Abstract
Rats receiving daily oral administrations of lindane were kindled using daily amygdaloid stimulation. In naive rats, lindane exposure increased the probability of evoking an afterdischarge and increased the probability that a convulsive response would be associated with the afterdischarge. During kindling, lindane increased the rate of acquisition of the fully kindled state. Lindane exposed rats required fewer stimulations, fewer afterdischarges and fewer seconds of afterdischarge to kindle. The final kindled state, however, was not modified by lindane exposure. The effects of lindane on kindling were directly proportional to exposure. A log-linear regression of the data estimated the minimal effective exposure level to be about 0.5 mg/kg/day lindane. Brain concentrations at this exposure were about 0.5 μg/g, while blood levels were near 0.1 μg/ml. The kindled seizure model appears to be a useful tool for estimating exposures at which certain neurotoxic responses emerge.
| Original language | English (US) |
|---|---|
| Pages (from-to) | 347-354 |
| Number of pages | 8 |
| Journal | Neurobehavioral Toxicology and Teratology |
| Volume | 4 |
| Issue number | 3 |
| State | Published - 1982 |
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ASJC Scopus subject areas
- Embryology
- Toxicology
- Neuropsychology and Physiological Psychology
Cite this
Proconvulsant effects of lindane : Enhancement of amygdaloid kindling in the rat. / Joy, R. M.; Stark, L. G.; Albertson, Timothy E.
In: Neurobehavioral Toxicology and Teratology, Vol. 4, No. 3, 1982, p. 347-354.Research output: Contribution to journal › Article
}
TY - JOUR
T1 - Proconvulsant effects of lindane
T2 - Enhancement of amygdaloid kindling in the rat
AU - Joy, R. M.
AU - Stark, L. G.
AU - Albertson, Timothy E
PY - 1982
Y1 - 1982
N2 - Rats receiving daily oral administrations of lindane were kindled using daily amygdaloid stimulation. In naive rats, lindane exposure increased the probability of evoking an afterdischarge and increased the probability that a convulsive response would be associated with the afterdischarge. During kindling, lindane increased the rate of acquisition of the fully kindled state. Lindane exposed rats required fewer stimulations, fewer afterdischarges and fewer seconds of afterdischarge to kindle. The final kindled state, however, was not modified by lindane exposure. The effects of lindane on kindling were directly proportional to exposure. A log-linear regression of the data estimated the minimal effective exposure level to be about 0.5 mg/kg/day lindane. Brain concentrations at this exposure were about 0.5 μg/g, while blood levels were near 0.1 μg/ml. The kindled seizure model appears to be a useful tool for estimating exposures at which certain neurotoxic responses emerge.
AB - Rats receiving daily oral administrations of lindane were kindled using daily amygdaloid stimulation. In naive rats, lindane exposure increased the probability of evoking an afterdischarge and increased the probability that a convulsive response would be associated with the afterdischarge. During kindling, lindane increased the rate of acquisition of the fully kindled state. Lindane exposed rats required fewer stimulations, fewer afterdischarges and fewer seconds of afterdischarge to kindle. The final kindled state, however, was not modified by lindane exposure. The effects of lindane on kindling were directly proportional to exposure. A log-linear regression of the data estimated the minimal effective exposure level to be about 0.5 mg/kg/day lindane. Brain concentrations at this exposure were about 0.5 μg/g, while blood levels were near 0.1 μg/ml. The kindled seizure model appears to be a useful tool for estimating exposures at which certain neurotoxic responses emerge.
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M3 - Article
C2 - 6178984
AN - SCOPUS:0019980250
VL - 4
SP - 347
EP - 354
JO - Neurotoxicology and Teratology
JF - Neurotoxicology and Teratology
SN - 0892-0362
IS - 3
ER -