Procoagulant property of platelet activating factor (PAF)

Gary W Raff, C. R. Spillert, D. J. Wilson, E. J. Lazaro

Research output: Contribution to journalArticle

3 Scopus citations

Abstract

Platelet-activating factor (PAF) is known to activate platelets and thus promote clot formation in most mammalian species including humans. In this communication, the ability of PAF to hasten the overall coagulation process by measuring the recalcification time (RT) is described. Assessment of the RT in vitro indicated that the RT was significantly reduced by PAF (p<0.001). This information adds a new dimension to the role of PAF in coagulation and also provides an exciting lead to the development of drugs for controlling the state of accelerated coagulation by pharmacologic means.

Original languageEnglish (US)
JournalAgents and Actions
Volume39
Issue number1 Supplement
DOIs
StatePublished - Mar 1993
Externally publishedYes

ASJC Scopus subject areas

  • Toxicology
  • Pharmacology (medical)

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  • Cite this

    Raff, G. W., Spillert, C. R., Wilson, D. J., & Lazaro, E. J. (1993). Procoagulant property of platelet activating factor (PAF). Agents and Actions, 39(1 Supplement). https://doi.org/10.1007/BF01972736