Procarbazine, lomustine, and vincristine (PCV) chemotherapy for grade III and grade IV oligoastrocytomas

Lyndon Kim, Fred H. Hochberg, Allan F. Thornton, Griffith R. Harsh IV, Heena Patel, Dianne Finkelstein, David N. Louis

Research output: Contribution to journalArticlepeer-review

130 Scopus citations

Abstract

The authors provided procarbazine, lomustine (CCNU), and vincristine (PCV) chemotherapy to 32 patients whose tumors contained varying mixtures of oligodendroglial and astrocytic cells. Twenty-five patients had oligodendroglioma astrocytoma (oligoastrocytoma) with a histological Grade of III (19 patients) or IV (six patients): seven had anaplastic oligodendroglioma. The PCV therapy was administered every 6 weeks for a total of at least 124 cycles. The median duration of follow-up review from the start of chemotherapy was 19.3 months. Nineteen patients were treated before receiving radiation therapy and 12 after receiving it (one patient received concurrent radiotherapy and chemotherapy). Grade 3 or 4 hematological toxicity was experienced by nine (31%) of 29 patients. Ten patients had delayed treatment due to treatment-related toxicities (34.5%). Ninety-one percent of the 32 patients responded to the therapy. These included 10 patients with a complete response and 19 with a partial response. The median time to progression was 15.4 months for all patients and 23.2 months for those with Grade III tumors. The median time to progression for patients with Grade III oligoastrocytomas was 13.8 months; for those with Grade IV oligoastrocytoma it was 12.4 months and for those with anaplastic oligodendrogliomas it was 63.4 months (p = 0.0348). These patients survived a median of 49.8 months. 16 months, and 76 or more months, respectively, from the start of chemotherapy (p = 0.0154). The PCV therapy provides durable responses in patients with Grade III or IV oligoastrocytomas.

Original languageEnglish (US)
Pages (from-to)602-607
Number of pages6
JournalJournal of Neurosurgery
Volume85
Issue number4
DOIs
StatePublished - Oct 1996
Externally publishedYes

Keywords

  • anaplastic oligodendroglioma
  • marker of oligodendroglial cells
  • oligoastrocytoma
  • percentage of oligodendroglioma component
  • procarbazine lomustine vincristine chemotherapy

ASJC Scopus subject areas

  • Surgery
  • Clinical Neurology

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