Probiotics and the gut microbiota in intestinal health and disease.

Melanie Gareau, Philip M. Sherman, W. Allan Walker

Research output: Contribution to journalArticle

368 Citations (Scopus)

Abstract

The use of probiotics is increasing in popularity for both the prevention and treatment of a variety of diseases. While a growing number of well-conducted, prospective, randomized, controlled, clinical trials are emerging and investigations of underlying mechanisms of action are being undertaken, questions remain with respect to the specific immune and physiological effects of probiotics in health and disease. This Review considers recent advances in clinical trials of probiotics for intestinal disorders in both adult and pediatric populations. An overview of recent in vitro and in vivo research related to potential mechanisms of action of various probiotic formulations is also considered.

Original languageEnglish (US)
Pages (from-to)503-514
Number of pages12
JournalNature reviews. Gastroenterology & hepatology
Volume7
Issue number9
StatePublished - Sep 2010
Externally publishedYes

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Intestinal Diseases
Probiotics
Health
Action Potentials
Randomized Controlled Trials
Clinical Trials
Pediatrics
Gastrointestinal Microbiome
Research
Population

ASJC Scopus subject areas

  • Medicine(all)

Cite this

Probiotics and the gut microbiota in intestinal health and disease. / Gareau, Melanie; Sherman, Philip M.; Walker, W. Allan.

In: Nature reviews. Gastroenterology & hepatology, Vol. 7, No. 9, 09.2010, p. 503-514.

Research output: Contribution to journalArticle

Gareau, Melanie ; Sherman, Philip M. ; Walker, W. Allan. / Probiotics and the gut microbiota in intestinal health and disease. In: Nature reviews. Gastroenterology & hepatology. 2010 ; Vol. 7, No. 9. pp. 503-514.
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