Probiotics and the gut microbiota in intestinal health and disease.

Melanie Gareau, Philip M. Sherman, W. Allan Walker

Research output: Contribution to journalArticlepeer-review

525 Scopus citations


The use of probiotics is increasing in popularity for both the prevention and treatment of a variety of diseases. While a growing number of well-conducted, prospective, randomized, controlled, clinical trials are emerging and investigations of underlying mechanisms of action are being undertaken, questions remain with respect to the specific immune and physiological effects of probiotics in health and disease. This Review considers recent advances in clinical trials of probiotics for intestinal disorders in both adult and pediatric populations. An overview of recent in vitro and in vivo research related to potential mechanisms of action of various probiotic formulations is also considered.

Original languageEnglish (US)
Pages (from-to)503-514
Number of pages12
JournalNature reviews. Gastroenterology & hepatology
Issue number9
StatePublished - Sep 2010
Externally publishedYes

ASJC Scopus subject areas

  • Medicine(all)


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