Probiotics and necrotizing enterocolitis

Ravi Mangal Patel, Mark Underwood

Research output: Contribution to journalArticle

25 Citations (Scopus)

Abstract

In this review, we summarize existing knowledge regarding the effects of probiotics on necrotizing enterocolitis (NEC). We review the role of the microbiome in NEC and pre-clinical data on mechanisms of probiotic action. Next, we summarize existing randomized controlled trials and observational studies of probiotics to prevent NEC. We also summarize findings from several recent meta-analyses and report a new cumulative meta-analysis of probiotic trials. Finally, we review data from cohorts routinely using commercially available probiotics. Our goal is to inform clinicians about the risks and benefits of probiotics, which may be helpful for those considering use in preterm infants to prevent NEC, death, or sepsis.

Original languageEnglish (US)
Pages (from-to)39-46
Number of pages8
JournalSeminars in Pediatric Surgery
Volume27
Issue number1
DOIs
StatePublished - Feb 1 2018

Fingerprint

Necrotizing Enterocolitis
Probiotics
Meta-Analysis
Microbiota
Premature Infants
Observational Studies
Sepsis
Randomized Controlled Trials

Keywords

  • Bacteria
  • Gut
  • Meta-analysis
  • Microbiome
  • Neonate
  • Preterm

ASJC Scopus subject areas

  • Pediatrics, Perinatology, and Child Health
  • Surgery

Cite this

Probiotics and necrotizing enterocolitis. / Patel, Ravi Mangal; Underwood, Mark.

In: Seminars in Pediatric Surgery, Vol. 27, No. 1, 01.02.2018, p. 39-46.

Research output: Contribution to journalArticle

Patel, Ravi Mangal ; Underwood, Mark. / Probiotics and necrotizing enterocolitis. In: Seminars in Pediatric Surgery. 2018 ; Vol. 27, No. 1. pp. 39-46.
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