Probiotics and innate and adaptive immune responses in premature infants

Research output: Contribution to journalReview article

6 Scopus citations

Abstract

Premature infants are at increased risk for morbidity and mortality due to necrotizing enterocolitis (NEC) and sepsis. Probiotics decrease the risk of NEC and death in premature infants; however, mechanisms of action are unclear. A wide variety of probiotic species have been evaluated for potential beneficial properties in vitro, in animal models, and in clinical trials of premature infants. Although there is variation by species and even strain, common mechanisms of protection include attenuation of intestinal inflammation, apoptosis, dysmotility, permeability, supplanting other gut microbes through production of bacteriocins, and more effective use of available nutrients. Here, we review the most promising probiotics and what is known about their impact on the innate and adaptive immune response.

Original languageEnglish (US)
Pages (from-to)1-15
Number of pages15
JournalForum on Immunopathological Diseases and Therapeutics
Volume7
Issue number1-2
DOIs
StatePublished - 2016

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Keywords

  • Bifidobacteria
  • Lactobacilli
  • Necrotizing enterocolitis
  • Probiotic
  • Sepsis

ASJC Scopus subject areas

  • Biotechnology
  • Biochemistry
  • Molecular Medicine
  • Genetics

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