Probiotic administration in congenital heart disease: A pilot study

C. L. Ellis, N. A. Bokulich, K. M. Kalanetra, M. Mirmiran, J. Elumalai, L. Haapanen, T. Schegg, John C Rutledge, Gary W Raff, D. A. Mills, Mark Underwood

Research output: Contribution to journalArticle

9 Citations (Scopus)

Abstract

Objective:To investigate the impact of probiotic Bifidobacterium longum ssp. infantis on the fecal microbiota and plasma cytokines in neonates with congenital heart disease.Study design:Sixteen infants with congenital heart disease were randomly assigned to receive either B. infantis (4.2 × 10 9 colony-forming units two times daily) or placebo for 8 weeks. Stool specimens from enrolled infants and from six term infants without heart disease were analyzed for microbial composition. Plasma cytokines were analyzed weekly in the infants with heart disease.Results:Healthy control infants had increased total bacteria, total Bacteroidetes and total bifidobacteria compared to the infants with heart disease, but there were no significant differences between the placebo and probiotic groups. Plasma interleukin (IL)10, interferon (IFN)γ and IL1β levels were transiently higher in the probiotic group.Conclusion:Congenital heart disease in infants is associated with dysbiosis. Probiotic B. infantis did not significantly alter the fecal microbiota. Alterations in plasma cytokines were found to be inconsistent.

Original languageEnglish (US)
Pages (from-to)691-697
Number of pages7
JournalJournal of Perinatology
Volume33
Issue number9
DOIs
StatePublished - Sep 2013

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Probiotics
Heart Diseases
Microbiota
Cytokines
Placebos
Dysbiosis
Bacteroidetes
Bifidobacterium
Interleukin-10
Interferons
Stem Cells
Newborn Infant
Bacteria

Keywords

  • bifidobacteria
  • congenital heart disease
  • microbiota
  • necrotizing enterocolitis
  • probiotic

ASJC Scopus subject areas

  • Obstetrics and Gynecology
  • Pediatrics, Perinatology, and Child Health

Cite this

Ellis, C. L., Bokulich, N. A., Kalanetra, K. M., Mirmiran, M., Elumalai, J., Haapanen, L., ... Underwood, M. (2013). Probiotic administration in congenital heart disease: A pilot study. Journal of Perinatology, 33(9), 691-697. https://doi.org/10.1038/jp.2013.41

Probiotic administration in congenital heart disease : A pilot study. / Ellis, C. L.; Bokulich, N. A.; Kalanetra, K. M.; Mirmiran, M.; Elumalai, J.; Haapanen, L.; Schegg, T.; Rutledge, John C; Raff, Gary W; Mills, D. A.; Underwood, Mark.

In: Journal of Perinatology, Vol. 33, No. 9, 09.2013, p. 691-697.

Research output: Contribution to journalArticle

Ellis, CL, Bokulich, NA, Kalanetra, KM, Mirmiran, M, Elumalai, J, Haapanen, L, Schegg, T, Rutledge, JC, Raff, GW, Mills, DA & Underwood, M 2013, 'Probiotic administration in congenital heart disease: A pilot study', Journal of Perinatology, vol. 33, no. 9, pp. 691-697. https://doi.org/10.1038/jp.2013.41
Ellis CL, Bokulich NA, Kalanetra KM, Mirmiran M, Elumalai J, Haapanen L et al. Probiotic administration in congenital heart disease: A pilot study. Journal of Perinatology. 2013 Sep;33(9):691-697. https://doi.org/10.1038/jp.2013.41
Ellis, C. L. ; Bokulich, N. A. ; Kalanetra, K. M. ; Mirmiran, M. ; Elumalai, J. ; Haapanen, L. ; Schegg, T. ; Rutledge, John C ; Raff, Gary W ; Mills, D. A. ; Underwood, Mark. / Probiotic administration in congenital heart disease : A pilot study. In: Journal of Perinatology. 2013 ; Vol. 33, No. 9. pp. 691-697.
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