Abstract
Probenecid retards the efflux of acid monoamine metabolites from the brain tissue and CSF to the blood. The probenecid-induced accumulation of these metabolites is held to be indicative of the turnover rate of the corresponding amines. Although the penetration of probenecid into the CSF does not proceed at a constant rate, Korf et al. (1972) and Sjöstrom (1972) have shown a correlation between CSF levels of probenecid and that of HVA and 5-HIAA. In this study an attempt was made to establish the relationship between doses of probenecid and levels of this compound in plasma and CSF; between levels in plasma and CSF; and between CSF levels of probenecid and of HVA and 5-HIAA. This study was performed in a homogeneous group of laboratory rabbits. All correlations proved to be significant. The implications of these results for studies using the probenecid technique are discussed.
Original language | English (US) |
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Pages (from-to) | 223-227 |
Number of pages | 5 |
Journal | Psychopharmacologia |
Volume | 43 |
Issue number | 3 |
DOIs | |
State | Published - Jan 1975 |
Externally published | Yes |
Keywords
- 5-Hydroxyindoleacetic Acid
- CSF
- Homovanillic Acid
- Probenecid
- Rabbits
ASJC Scopus subject areas
- Pharmacology
- Medicine(all)