Probenecid: Dosage, levels in plasma and cerebrospinal fluid (CSF) and influence upon CSF levels of homovanillic acid (HVA) and 5-hydroxyindoleacetic acid (5-HIAA) in the rabbit

Jan Paul Muizelaar, J. I. Oberink

Research output: Contribution to journalArticlepeer-review

5 Scopus citations

Abstract

Probenecid retards the efflux of acid monoamine metabolites from the brain tissue and CSF to the blood. The probenecid-induced accumulation of these metabolites is held to be indicative of the turnover rate of the corresponding amines. Although the penetration of probenecid into the CSF does not proceed at a constant rate, Korf et al. (1972) and Sjöstrom (1972) have shown a correlation between CSF levels of probenecid and that of HVA and 5-HIAA. In this study an attempt was made to establish the relationship between doses of probenecid and levels of this compound in plasma and CSF; between levels in plasma and CSF; and between CSF levels of probenecid and of HVA and 5-HIAA. This study was performed in a homogeneous group of laboratory rabbits. All correlations proved to be significant. The implications of these results for studies using the probenecid technique are discussed.

Original languageEnglish (US)
Pages (from-to)223-227
Number of pages5
JournalPsychopharmacologia
Volume43
Issue number3
DOIs
StatePublished - Jan 1975
Externally publishedYes

Keywords

  • 5-Hydroxyindoleacetic Acid
  • CSF
  • Homovanillic Acid
  • Probenecid
  • Rabbits

ASJC Scopus subject areas

  • Pharmacology
  • Medicine(all)

Fingerprint Dive into the research topics of 'Probenecid: Dosage, levels in plasma and cerebrospinal fluid (CSF) and influence upon CSF levels of homovanillic acid (HVA) and 5-hydroxyindoleacetic acid (5-HIAA) in the rabbit'. Together they form a unique fingerprint.

Cite this