Probe sialidase substrate specificity using chemoenzymatically synthesized sialosides containing C9-modified sialic acid

Zahra Khedri, Musleh M. Muthana, Yanhong Li, Saddam M. Muthana, Hai Yu, Hongzhi Cao, Xi Chen

Research output: Contribution to journalArticle

26 Citations (Scopus)

Abstract

A library of α2-3- and α2-6-linked sialyl galactosides containing C9-modified sialic acids was synthesized from C6-modified mannose derivatives using an efficient one-pot three-enzyme system. These sialosides were used in a high-throughput sialidase substrate specificity assay to elucidate the importance of C9-OH in sialidase recognition.

Original languageEnglish (US)
Pages (from-to)3357-3359
Number of pages3
JournalChemical Communications
Volume48
Issue number27
DOIs
StatePublished - Apr 4 2012

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Neuraminidase
N-Acetylneuraminic Acid
Assays
Enzymes
Throughput
Sialic Acids
Derivatives
Galactosides
Acids
Substrates
Mannose

ASJC Scopus subject areas

  • Metals and Alloys
  • Materials Chemistry
  • Surfaces, Coatings and Films
  • Electronic, Optical and Magnetic Materials
  • Ceramics and Composites
  • Catalysis
  • Chemistry(all)

Cite this

Probe sialidase substrate specificity using chemoenzymatically synthesized sialosides containing C9-modified sialic acid. / Khedri, Zahra; Muthana, Musleh M.; Li, Yanhong; Muthana, Saddam M.; Yu, Hai; Cao, Hongzhi; Chen, Xi.

In: Chemical Communications, Vol. 48, No. 27, 04.04.2012, p. 3357-3359.

Research output: Contribution to journalArticle

Khedri, Zahra ; Muthana, Musleh M. ; Li, Yanhong ; Muthana, Saddam M. ; Yu, Hai ; Cao, Hongzhi ; Chen, Xi. / Probe sialidase substrate specificity using chemoenzymatically synthesized sialosides containing C9-modified sialic acid. In: Chemical Communications. 2012 ; Vol. 48, No. 27. pp. 3357-3359.
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