Probe sialidase substrate specificity using chemoenzymatically synthesized sialosides containing C9-modified sialic acid

Zahra Khedri, Musleh M. Muthana, Yanhong Li, Saddam M. Muthana, Hai Yu, Hongzhi Cao, Xi Chen

Research output: Contribution to journalArticle

29 Scopus citations

Abstract

A library of α2-3- and α2-6-linked sialyl galactosides containing C9-modified sialic acids was synthesized from C6-modified mannose derivatives using an efficient one-pot three-enzyme system. These sialosides were used in a high-throughput sialidase substrate specificity assay to elucidate the importance of C9-OH in sialidase recognition.

Original languageEnglish (US)
Pages (from-to)3357-3359
Number of pages3
JournalChemical Communications
Volume48
Issue number27
DOIs
StatePublished - Apr 4 2012

ASJC Scopus subject areas

  • Metals and Alloys
  • Materials Chemistry
  • Surfaces, Coatings and Films
  • Electronic, Optical and Magnetic Materials
  • Ceramics and Composites
  • Catalysis
  • Chemistry(all)

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