Probable essential thrombocythemia in a dog.

P. E. Hopper, C. P. Mandell, J. M. Turrel, N. C. Jain, Fern Tablin, J. G. Zinkl

Research output: Contribution to journalArticle

25 Scopus citations

Abstract

Essential thrombocythemia (ET) in an 11-year-old dog was characterized by persistently high platelet counts (range, 4.19 X 10(6)/microliters to 4.95 X 10(6)/microliters, abnormal platelet morphology, marked megakaryocytic hyperplasia in the bone marrow, absence of circulating megakaryoblasts, and history of splenomegaly and gastrointestinal bleeding. Increased numbers of megakaryocytes and megakaryoblasts (15% to 20%) in the bone marrow were confirmed by a positive acetylcholinesterase reaction. Another significant finding was the presence of a basophilia in blood (4,836/microliters) and bone marrow. The marked persistent thrombocytosis, absence of reactive (secondary) thrombocytosis, abnormal platelet morphology, and quantitative and qualitative changes in the megakaryocytic series in the bone marrow suggested the presence of a myeloproliferative disease. Cytochemical and ultrastructural findings aided in the diagnosis of ET. The dog was treated with radiophosphorus. The results was a rapid decline in the numbers of megakaryoblasts and megakaryocytes in the bone marrow and platelets and basophils in the peripheral blood. The dog died unexpectedly of acute necrotizing pancreatitis and diabetes mellitus before a complete remission was achieved.

Original languageEnglish (US)
Pages (from-to)79-85
Number of pages7
JournalJournal of veterinary internal medicine / American College of Veterinary Internal Medicine
Volume3
Issue number2
StatePublished - Apr 1989

ASJC Scopus subject areas

  • veterinary(all)

Fingerprint Dive into the research topics of 'Probable essential thrombocythemia in a dog.'. Together they form a unique fingerprint.

  • Cite this

    Hopper, P. E., Mandell, C. P., Turrel, J. M., Jain, N. C., Tablin, F., & Zinkl, J. G. (1989). Probable essential thrombocythemia in a dog. Journal of veterinary internal medicine / American College of Veterinary Internal Medicine, 3(2), 79-85.