Proactive and reactive cognitive control and dorsolateral prefrontal cortex dysfunction in first episode schizophrenia

Tyler A. Lesh, Andrew J. Westphal, Tara A Niendam, Jong H. Yoon, Michael J. Minzenberg, John D Ragland, Marjorie Solomon Friedman, Cameron S Carter

Research output: Contribution to journalArticle

69 Citations (Scopus)

Abstract

Cognitive control deficits have been consistently documented in patients with schizophrenia. Recent work in cognitive neuroscience has hypothesized a distinction between two theoretically separable modes of cognitive control - reactive and proactive. However, it remains unclear the extent to which these processes are uniquely associated with dysfunctional neural recruitment in individuals with schizophrenia. This functional magnetic resonance imaging (fMRI) study utilized the color word Stroop task and AX Continuous Performance Task (AX-CPT) to tap reactive and proactive control processes, respectively, in a sample of 54 healthy controls and 43 patients with first episode schizophrenia. Healthy controls demonstrated robust dorsolateral prefrontal, anterior cingulate, and parietal cortex activity on both tasks. In contrast, patients with schizophrenia did not show any significant activation during proactive control, while showing activation similar to control subjects during reactive control. Critically, an interaction analysis showed that the degree to which prefrontal activity was reduced in patients versus controls depended on the type of control process engaged. Controls showed increased dorsolateral prefrontal cortex (DLPFC) and parietal activity in the proactive compared to the reactive control task, whereas patients with schizophrenia did not demonstrate this increase. Additionally, patients' DLPFC activity and performance during proactive control was associated with disorganization symptoms, while no reactive control measures showed this association. Proactive control processes and concomitant dysfunctional recruitment of DLPFC represent robust features of schizophrenia that are also directly associated with symptoms of disorganization.

Original languageEnglish (US)
Pages (from-to)590-599
Number of pages10
JournalNeuroImage: Clinical
Volume2
Issue number1
DOIs
StatePublished - 2013

Fingerprint

Prefrontal Cortex
Schizophrenia
Somatosensory Cortex
Gyrus Cinguli
Task Performance and Analysis
Color
Magnetic Resonance Imaging

Keywords

  • AX-CPT
  • Cognitive control
  • DLPFC
  • fMRI
  • Schizophrenia
  • Stroop

ASJC Scopus subject areas

  • Clinical Neurology
  • Radiology Nuclear Medicine and imaging
  • Cognitive Neuroscience
  • Neurology

Cite this

Proactive and reactive cognitive control and dorsolateral prefrontal cortex dysfunction in first episode schizophrenia. / Lesh, Tyler A.; Westphal, Andrew J.; Niendam, Tara A; Yoon, Jong H.; Minzenberg, Michael J.; Ragland, John D; Friedman, Marjorie Solomon; Carter, Cameron S.

In: NeuroImage: Clinical, Vol. 2, No. 1, 2013, p. 590-599.

Research output: Contribution to journalArticle

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