Principles of surgery for malignant astrocytomas

Eli T. Sayegh, Taemin Oh, Shayan Fakurnejad, Daniel E. Oyon, Orin Bloch, Andrew T. Parsa

Research output: Contribution to journalArticle

2 Citations (Scopus)

Abstract

Malignant astrocytomas constitute the most aggressive and common primary tumors of the central nervous system. The standard treatment protocol for these tumors involves maximum safe surgical resection with adjuvant chemoradiotherapy. Despite numerous advances in surgical techniques and adjuncts, as well as the ongoing renaissance in the genetic and molecular characterization of these tumors, malignant astrocytomas continue to be associated with poor prognosis, with median overall survival averaging 15 months for grade IV astrocytomas after standard-of-care treatment. In this article, the goals, principles, techniques, prognostic factors, and modern outcomes of malignant astrocytoma surgery are reviewed. Particular attention is paid to contemporary methods of neuronavigation and functional mapping, the prognostic significance of the extent of resection, surgically delivered adjunctive therapies, and future avenues of research.

Original languageEnglish (US)
Pages (from-to)523-531
Number of pages9
JournalSeminars in oncology
Volume41
Issue number4
DOIs
StatePublished - Aug 2014
Externally publishedYes

Fingerprint

Astrocytoma
Adjuvant Chemoradiotherapy
Neuronavigation
Central Nervous System Neoplasms
Glioblastoma
Standard of Care
Clinical Protocols
Molecular Biology
Neoplasms
Therapeutics
Research

ASJC Scopus subject areas

  • Hematology
  • Oncology

Cite this

Sayegh, E. T., Oh, T., Fakurnejad, S., Oyon, D. E., Bloch, O., & Parsa, A. T. (2014). Principles of surgery for malignant astrocytomas. Seminars in oncology, 41(4), 523-531. https://doi.org/10.1053/j.seminoncol.2014.06.011

Principles of surgery for malignant astrocytomas. / Sayegh, Eli T.; Oh, Taemin; Fakurnejad, Shayan; Oyon, Daniel E.; Bloch, Orin; Parsa, Andrew T.

In: Seminars in oncology, Vol. 41, No. 4, 08.2014, p. 523-531.

Research output: Contribution to journalArticle

Sayegh, ET, Oh, T, Fakurnejad, S, Oyon, DE, Bloch, O & Parsa, AT 2014, 'Principles of surgery for malignant astrocytomas', Seminars in oncology, vol. 41, no. 4, pp. 523-531. https://doi.org/10.1053/j.seminoncol.2014.06.011
Sayegh, Eli T. ; Oh, Taemin ; Fakurnejad, Shayan ; Oyon, Daniel E. ; Bloch, Orin ; Parsa, Andrew T. / Principles of surgery for malignant astrocytomas. In: Seminars in oncology. 2014 ; Vol. 41, No. 4. pp. 523-531.
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