Abstract
Malignant astrocytomas constitute the most aggressive and common primary tumors of the central nervous system. The standard treatment protocol for these tumors involves maximum safe surgical resection with adjuvant chemoradiotherapy. Despite numerous advances in surgical techniques and adjuncts, as well as the ongoing renaissance in the genetic and molecular characterization of these tumors, malignant astrocytomas continue to be associated with poor prognosis, with median overall survival averaging 15 months for grade IV astrocytomas after standard-of-care treatment. In this article, the goals, principles, techniques, prognostic factors, and modern outcomes of malignant astrocytoma surgery are reviewed. Particular attention is paid to contemporary methods of neuronavigation and functional mapping, the prognostic significance of the extent of resection, surgically delivered adjunctive therapies, and future avenues of research.
| Original language | English (US) |
|---|---|
| Pages (from-to) | 523-531 |
| Number of pages | 9 |
| Journal | Seminars in oncology |
| Volume | 41 |
| Issue number | 4 |
| DOIs | |
| State | Published - Aug 2014 |
| Externally published | Yes |
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ASJC Scopus subject areas
- Hematology
- Oncology
Cite this
Principles of surgery for malignant astrocytomas. / Sayegh, Eli T.; Oh, Taemin; Fakurnejad, Shayan; Oyon, Daniel E.; Bloch, Orin; Parsa, Andrew T.
In: Seminars in oncology, Vol. 41, No. 4, 08.2014, p. 523-531.Research output: Contribution to journal › Article
}
TY - JOUR
T1 - Principles of surgery for malignant astrocytomas
AU - Sayegh, Eli T.
AU - Oh, Taemin
AU - Fakurnejad, Shayan
AU - Oyon, Daniel E.
AU - Bloch, Orin
AU - Parsa, Andrew T.
PY - 2014/8
Y1 - 2014/8
N2 - Malignant astrocytomas constitute the most aggressive and common primary tumors of the central nervous system. The standard treatment protocol for these tumors involves maximum safe surgical resection with adjuvant chemoradiotherapy. Despite numerous advances in surgical techniques and adjuncts, as well as the ongoing renaissance in the genetic and molecular characterization of these tumors, malignant astrocytomas continue to be associated with poor prognosis, with median overall survival averaging 15 months for grade IV astrocytomas after standard-of-care treatment. In this article, the goals, principles, techniques, prognostic factors, and modern outcomes of malignant astrocytoma surgery are reviewed. Particular attention is paid to contemporary methods of neuronavigation and functional mapping, the prognostic significance of the extent of resection, surgically delivered adjunctive therapies, and future avenues of research.
AB - Malignant astrocytomas constitute the most aggressive and common primary tumors of the central nervous system. The standard treatment protocol for these tumors involves maximum safe surgical resection with adjuvant chemoradiotherapy. Despite numerous advances in surgical techniques and adjuncts, as well as the ongoing renaissance in the genetic and molecular characterization of these tumors, malignant astrocytomas continue to be associated with poor prognosis, with median overall survival averaging 15 months for grade IV astrocytomas after standard-of-care treatment. In this article, the goals, principles, techniques, prognostic factors, and modern outcomes of malignant astrocytoma surgery are reviewed. Particular attention is paid to contemporary methods of neuronavigation and functional mapping, the prognostic significance of the extent of resection, surgically delivered adjunctive therapies, and future avenues of research.
UR - http://www.scopus.com/inward/record.url?scp=84906736480&partnerID=8YFLogxK
UR - http://www.scopus.com/inward/citedby.url?scp=84906736480&partnerID=8YFLogxK
U2 - 10.1053/j.seminoncol.2014.06.011
DO - 10.1053/j.seminoncol.2014.06.011
M3 - Article
C2 - 25173144
AN - SCOPUS:84906736480
VL - 41
SP - 523
EP - 531
JO - Seminars in Oncology
JF - Seminars in Oncology
SN - 0093-7754
IS - 4
ER -