Principles of Nonunion Management: State of the Art

Aaron Nauth, Mark A Lee, Michael J. Gardner, Mark R. Brinker, Stephen J. Warner, Paul Tornetta, Philipp Leucht

Research output: Contribution to journalArticle

4 Citations (Scopus)

Abstract

A substantial proportion of fractures can present with nonunion, and the management of nonunion continues to present a challenge for orthopaedic surgeons. A variety of biological, mechanical, patient, and injury factors can contribute to the occurrence of nonunion, and often the cause of nonunion may be multifactorial. Successful management often requires assessment and treatment of more than one of these factors. This article reviews common factors that may contribute to nonunion including infection, impaired biology, and metabolic disorders. In addition, new and evolving strategies for diagnosing the cause and effectively treating nonunion including the diagnosis of infection, metabolic workup, bone grafting, cell-based therapies, and biological adjuvants are reviewed and discussed.

Original languageEnglish (US)
Pages (from-to)S52-S57
JournalJournal of Orthopaedic Trauma
Volume32
DOIs
StatePublished - Mar 1 2018

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Bone Transplantation
Cell- and Tissue-Based Therapy
Infection
Wounds and Injuries
Therapeutics
Orthopedic Surgeons

Keywords

  • bone graft
  • fracture healing
  • infection
  • metabolic causes of nonunion
  • nonunion
  • stem cells

ASJC Scopus subject areas

  • Surgery
  • Orthopedics and Sports Medicine

Cite this

Nauth, A., Lee, M. A., Gardner, M. J., Brinker, M. R., Warner, S. J., Tornetta, P., & Leucht, P. (2018). Principles of Nonunion Management: State of the Art. Journal of Orthopaedic Trauma, 32, S52-S57. https://doi.org/10.1097/BOT.0000000000001122

Principles of Nonunion Management : State of the Art. / Nauth, Aaron; Lee, Mark A; Gardner, Michael J.; Brinker, Mark R.; Warner, Stephen J.; Tornetta, Paul; Leucht, Philipp.

In: Journal of Orthopaedic Trauma, Vol. 32, 01.03.2018, p. S52-S57.

Research output: Contribution to journalArticle

Nauth, A, Lee, MA, Gardner, MJ, Brinker, MR, Warner, SJ, Tornetta, P & Leucht, P 2018, 'Principles of Nonunion Management: State of the Art', Journal of Orthopaedic Trauma, vol. 32, pp. S52-S57. https://doi.org/10.1097/BOT.0000000000001122
Nauth A, Lee MA, Gardner MJ, Brinker MR, Warner SJ, Tornetta P et al. Principles of Nonunion Management: State of the Art. Journal of Orthopaedic Trauma. 2018 Mar 1;32:S52-S57. https://doi.org/10.1097/BOT.0000000000001122
Nauth, Aaron ; Lee, Mark A ; Gardner, Michael J. ; Brinker, Mark R. ; Warner, Stephen J. ; Tornetta, Paul ; Leucht, Philipp. / Principles of Nonunion Management : State of the Art. In: Journal of Orthopaedic Trauma. 2018 ; Vol. 32. pp. S52-S57.
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