Principal component analysis of the T wave: 24 Hour monitoring of repolarization complexity in dialysis patients

Stefano Severi, Eleonora Grandi, G. Alessandrini, A. Santoro, S. Cavalcanti

Research output: Chapter in Book/Report/Conference proceedingConference contribution

1 Scopus citations

Abstract

The 24-hour changes in the complexity of ventricular repolarization in hemodialysis (HD) patients were quantified by principal component analysis (PCA) of the T wave. The effects of dialysis sessions leading to different plasma potassium levels ('Klow' and 'Khigh') were analyzed. Forty-six Holter recordings were collected from twelve patients. PCA was applied to the T waves extracted from each beat. Repolarization complexity was quantified by the ratio of the second to the first eigenvalue (PCA ratio). Hemodialysis caused a significant increase in the PCA ratio (+50% at the end of the sessions), which recovered to the basal value during the first hour post-dialysis. In the last two hours of dialysis PCA ratio was significantly higher in Klow sessions than in Khigh ones. Results show a significant HD-induced increase of the T wave complexity, strongly related to the therapy-induced potassium depletion.

Original languageEnglish (US)
Title of host publication2006 Computers in Cardiology, CIC
Pages701-704
Number of pages4
Volume33
StatePublished - Dec 1 2006
Externally publishedYes
Event2006 Computers in Cardiology, CIC - Valencia, Spain
Duration: Sep 17 2006Sep 20 2006

Other

Other2006 Computers in Cardiology, CIC
CountrySpain
CityValencia
Period9/17/069/20/06

ASJC Scopus subject areas

  • Cardiology and Cardiovascular Medicine
  • Software

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    Severi, S., Grandi, E., Alessandrini, G., Santoro, A., & Cavalcanti, S. (2006). Principal component analysis of the T wave: 24 Hour monitoring of repolarization complexity in dialysis patients. In 2006 Computers in Cardiology, CIC (Vol. 33, pp. 701-704). [4511948]