Primate cytomegaloviruses encode and express an IL-10-like protein

Kristen M. Lockridge, Shan Shan Zhou, Rachel H. Kravitz, Jennifer L. Johnson, Earl T. Sawai, Earl L. Blewett, Peter A Barry

Research output: Contribution to journalArticle

128 Citations (Scopus)

Abstract

An open reading frame (ORF) with homology to interleukin-10 (IL-10) has been identified in rhesus cytomegalovirus (RhCMV). The IL-10-like protein is generated from a multispliced, polyadenylated early gene transcript encompassing part of the corresponding UL111A ORF of human CMV (HCMV). Immunological analyses confirm expression of the IL-10-like protein both in tissue culture and in RhCMV-infected rhesus macaques. Conserved ORFs were subsequently identified in human, baboon, and African green monkey CMV, and a fully processed transcript has been mapped in fibroblasts infected with the Towne strain of HCMV. The conservation of this previously unrecognized ORF suggests that the protein may play an essential role in primate CMV persistence and pathogenesis. (C) 2000 Academic Press.

Original languageEnglish (US)
Pages (from-to)272-280
Number of pages9
JournalVirology
Volume268
Issue number2
DOIs
StatePublished - Mar 15 2000

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Cytomegalovirus
Interleukin-10
Primates
Open Reading Frames
Proteins
Cercopithecus aethiops
Papio
Macaca mulatta
Fibroblasts
Genes

ASJC Scopus subject areas

  • Virology
  • Infectious Diseases

Cite this

Lockridge, K. M., Zhou, S. S., Kravitz, R. H., Johnson, J. L., Sawai, E. T., Blewett, E. L., & Barry, P. A. (2000). Primate cytomegaloviruses encode and express an IL-10-like protein. Virology, 268(2), 272-280. https://doi.org/10.1006/viro.2000.0195

Primate cytomegaloviruses encode and express an IL-10-like protein. / Lockridge, Kristen M.; Zhou, Shan Shan; Kravitz, Rachel H.; Johnson, Jennifer L.; Sawai, Earl T.; Blewett, Earl L.; Barry, Peter A.

In: Virology, Vol. 268, No. 2, 15.03.2000, p. 272-280.

Research output: Contribution to journalArticle

Lockridge, KM, Zhou, SS, Kravitz, RH, Johnson, JL, Sawai, ET, Blewett, EL & Barry, PA 2000, 'Primate cytomegaloviruses encode and express an IL-10-like protein', Virology, vol. 268, no. 2, pp. 272-280. https://doi.org/10.1006/viro.2000.0195
Lockridge KM, Zhou SS, Kravitz RH, Johnson JL, Sawai ET, Blewett EL et al. Primate cytomegaloviruses encode and express an IL-10-like protein. Virology. 2000 Mar 15;268(2):272-280. https://doi.org/10.1006/viro.2000.0195
Lockridge, Kristen M. ; Zhou, Shan Shan ; Kravitz, Rachel H. ; Johnson, Jennifer L. ; Sawai, Earl T. ; Blewett, Earl L. ; Barry, Peter A. / Primate cytomegaloviruses encode and express an IL-10-like protein. In: Virology. 2000 ; Vol. 268, No. 2. pp. 272-280.
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