TY - JOUR
T1 - Primary Sjogren's syndrome and primary biliary cirrhosis
T2 - Differences and similarities in the autoantibody profile
AU - Tishler, M.
AU - Alosachie, I.
AU - Barka, N.
AU - Lin, H. C.
AU - Gershwin, M. Eric
AU - Peter, J. B.
AU - Shoenfeld, Y.
PY - 1995
Y1 - 1995
N2 - Sera from 61 patients with primary biliary cirrhosis (PBC) and 23 patients with primary Sjogren's syndrome (PSS) were tested for the presence of autoantibodies to 15 different antigens (PDH, RNP, SS-A, SS-B, Sm, Scl-70, H2AH2B, Jo-1, collagen-type I, GBM, GM <--> 1, Sulf, GD1b, MPO, PR3). Patients with pSS had significantly (p < 0.01) higher frequencies of antibodies to SS-A, SS-B and RNP (78%, 52%, 22% vs 29%, 20%, 5%, respectively) when compared to patients with PBC. On the other hand, patients with PBC had significantly (p < 0.01) higher frequencies of antibodies to PDH, Sm, Jo-1, collagen and MPO (80%, 34%, 26%, 52%, 67% vs 13%, 9%, 13%, 13%, 9%, respectively) as compared with patients with pSS. For all the other autoantibodies, no significant differences were found between PBS and pSS patients. These data on the similarities in autoimmunity between two diseases with different clinical presentations shed more light on the mosaic of autoimmunity.
AB - Sera from 61 patients with primary biliary cirrhosis (PBC) and 23 patients with primary Sjogren's syndrome (PSS) were tested for the presence of autoantibodies to 15 different antigens (PDH, RNP, SS-A, SS-B, Sm, Scl-70, H2AH2B, Jo-1, collagen-type I, GBM, GM <--> 1, Sulf, GD1b, MPO, PR3). Patients with pSS had significantly (p < 0.01) higher frequencies of antibodies to SS-A, SS-B and RNP (78%, 52%, 22% vs 29%, 20%, 5%, respectively) when compared to patients with PBC. On the other hand, patients with PBC had significantly (p < 0.01) higher frequencies of antibodies to PDH, Sm, Jo-1, collagen and MPO (80%, 34%, 26%, 52%, 67% vs 13%, 9%, 13%, 13%, 9%, respectively) as compared with patients with pSS. For all the other autoantibodies, no significant differences were found between PBS and pSS patients. These data on the similarities in autoimmunity between two diseases with different clinical presentations shed more light on the mosaic of autoimmunity.
KW - autoimmunity
KW - PBC
KW - Sjogren's syndrome
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M3 - Article
C2 - 7586784
AN - SCOPUS:0028991753
VL - 13
SP - 497
EP - 500
JO - Clinical and Experimental Rheumatology
JF - Clinical and Experimental Rheumatology
SN - 0392-856X
IS - 4
ER -