Primary Sclerosing Cholangitis. Multiple Phenotypes, Multiple Approaches.

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24 Scopus citations


Primary sclerosing cholangitis (PSC) is a heterogeneous, idiopathic, inflammatory disorder frequently associated with inflammatory bowel diseases. PSC patients may be classified into several subphenotypes. Investigations of pediatric, nonwhite, and female PSC patients have revealed distinguishing features. The natural history of PSC is variable in progression with numerous possible clinical outcomes. PSC patients may suffer bacterial cholangitis, cholangiocarcinoma, or colorectal adenocarcinoma. Treatments focusing on bile acid therapy and immunosuppression have not proven beneficial. Interest in PSC and international collaboration has led to improved understanding of the heterogeneity and the genetic structure and introduced possible effective therapeutics.

Original languageEnglish (US)
Pages (from-to)67-77
Number of pages11
JournalClinics in Liver Disease
Issue number1
StatePublished - Feb 1 2016


  • Autoimmune hepatitis
  • Diagnosis
  • IgG4-related sclerosing cholangitis
  • Primary sclerosing cholangitis
  • Treatment

ASJC Scopus subject areas

  • Hepatology


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