Primary Laryngeal Blastomycosis: Diagnostic Challenges and Advances in a Rare Cause of Laryngitis

Daniel Cates, Clark A. Rosen, Mohamed H. Yassin, Libby J. Smith

Research output: Contribution to journalArticle

Abstract

Blastomyces dermatitidis is a fungal organism endemic to the central and southern United States and capable of causing numerous diseases. Primary blastomycosis of the larynx is a rare clinical entity with a limited number of reported cases in the literature. Diagnosis is challenging as a result of nonspecific physical exam findings, difficulty of histopathologic detection and culture, and need for operative laryngeal biopsy for definitive identification. Molecular and serologic testing is not widely available. The authors present a case of laryngeal blastomycosis, the diagnosis of which was facilitated by in-office biopsy, and discuss diagnostic challenges.

Original languageEnglish (US)
JournalLaryngoscope
DOIs
StatePublished - Jan 1 2019
Externally publishedYes

Fingerprint

Blastomycosis
Laryngitis
Blastomyces
Biopsy
Larynx

Keywords

  • Blastomyces dermatitidis
  • Blastomycosis
  • fungal laryngitis
  • laryngeal

ASJC Scopus subject areas

  • Otorhinolaryngology

Cite this

Primary Laryngeal Blastomycosis : Diagnostic Challenges and Advances in a Rare Cause of Laryngitis. / Cates, Daniel; Rosen, Clark A.; Yassin, Mohamed H.; Smith, Libby J.

In: Laryngoscope, 01.01.2019.

Research output: Contribution to journalArticle

@article{374f82fbc6b34e22852a923d6fe82e84,
title = "Primary Laryngeal Blastomycosis: Diagnostic Challenges and Advances in a Rare Cause of Laryngitis",
abstract = "Blastomyces dermatitidis is a fungal organism endemic to the central and southern United States and capable of causing numerous diseases. Primary blastomycosis of the larynx is a rare clinical entity with a limited number of reported cases in the literature. Diagnosis is challenging as a result of nonspecific physical exam findings, difficulty of histopathologic detection and culture, and need for operative laryngeal biopsy for definitive identification. Molecular and serologic testing is not widely available. The authors present a case of laryngeal blastomycosis, the diagnosis of which was facilitated by in-office biopsy, and discuss diagnostic challenges.",
keywords = "Blastomyces dermatitidis, Blastomycosis, fungal laryngitis, laryngeal",
author = "Daniel Cates and Rosen, {Clark A.} and Yassin, {Mohamed H.} and Smith, {Libby J.}",
year = "2019",
month = "1",
day = "1",
doi = "10.1002/lary.27593",
language = "English (US)",
journal = "Laryngoscope",
issn = "0023-852X",
publisher = "Wiley-Blackwell",

}

TY - JOUR

T1 - Primary Laryngeal Blastomycosis

T2 - Diagnostic Challenges and Advances in a Rare Cause of Laryngitis

AU - Cates, Daniel

AU - Rosen, Clark A.

AU - Yassin, Mohamed H.

AU - Smith, Libby J.

PY - 2019/1/1

Y1 - 2019/1/1

N2 - Blastomyces dermatitidis is a fungal organism endemic to the central and southern United States and capable of causing numerous diseases. Primary blastomycosis of the larynx is a rare clinical entity with a limited number of reported cases in the literature. Diagnosis is challenging as a result of nonspecific physical exam findings, difficulty of histopathologic detection and culture, and need for operative laryngeal biopsy for definitive identification. Molecular and serologic testing is not widely available. The authors present a case of laryngeal blastomycosis, the diagnosis of which was facilitated by in-office biopsy, and discuss diagnostic challenges.

AB - Blastomyces dermatitidis is a fungal organism endemic to the central and southern United States and capable of causing numerous diseases. Primary blastomycosis of the larynx is a rare clinical entity with a limited number of reported cases in the literature. Diagnosis is challenging as a result of nonspecific physical exam findings, difficulty of histopathologic detection and culture, and need for operative laryngeal biopsy for definitive identification. Molecular and serologic testing is not widely available. The authors present a case of laryngeal blastomycosis, the diagnosis of which was facilitated by in-office biopsy, and discuss diagnostic challenges.

KW - Blastomyces dermatitidis

KW - Blastomycosis

KW - fungal laryngitis

KW - laryngeal

UR - http://www.scopus.com/inward/record.url?scp=85066884592&partnerID=8YFLogxK

UR - http://www.scopus.com/inward/citedby.url?scp=85066884592&partnerID=8YFLogxK

U2 - 10.1002/lary.27593

DO - 10.1002/lary.27593

M3 - Article

C2 - 31120608

AN - SCOPUS:85066884592

JO - Laryngoscope

JF - Laryngoscope

SN - 0023-852X

ER -