Primary intraosseous schwannoma in tibial epiphysis with unique immunohistochemical phenotype: A case report

Tao Wang, Juan M. Giugale, Ming Ding, Mark A. Goodman, Karen Schoedel, Uma N.M. Rao

Research output: Contribution to journalArticle

2 Citations (Scopus)

Abstract

Schwannoma is a benign peripheral nerve sheath neoplasm of soft tissue that consistently demonstrates immunohistochemical staining for S100 protein. Intraosseous location of schwannoma is very uncommon. We report the first case of an intraosseous schwannoma located in the epiphysis of tibia in an adult patient. Radiologically, it mimicked a primary bone tumor and despite benign histological appearance, the tumor eroded cortical bone. Morphologically on routine stains and electron microscopy it has features of a schwannoma. But by immunohistochemistry, the tumor was positive for both desmin and S100 protein in the same region.

Original languageEnglish (US)
Pages (from-to)574-578
Number of pages5
JournalInternational Journal of Surgical Pathology
Volume22
Issue number6
DOIs
StatePublished - 2014
Externally publishedYes

Fingerprint

Epiphyses
Neurilemmoma
Phenotype
S100 Proteins
Peripheral Nervous System Neoplasms
Nerve Sheath Neoplasms
Neoplasms
Desmin
Tibia
Electron Microscopy
Coloring Agents
Immunohistochemistry
Staining and Labeling
Bone and Bones

Keywords

  • primary intraosseous schwannoma
  • tibial epiphysis

ASJC Scopus subject areas

  • Anatomy
  • Surgery
  • Pathology and Forensic Medicine

Cite this

Primary intraosseous schwannoma in tibial epiphysis with unique immunohistochemical phenotype : A case report. / Wang, Tao; Giugale, Juan M.; Ding, Ming; Goodman, Mark A.; Schoedel, Karen; Rao, Uma N.M.

In: International Journal of Surgical Pathology, Vol. 22, No. 6, 2014, p. 574-578.

Research output: Contribution to journalArticle

Wang, Tao ; Giugale, Juan M. ; Ding, Ming ; Goodman, Mark A. ; Schoedel, Karen ; Rao, Uma N.M. / Primary intraosseous schwannoma in tibial epiphysis with unique immunohistochemical phenotype : A case report. In: International Journal of Surgical Pathology. 2014 ; Vol. 22, No. 6. pp. 574-578.
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