Abstract
A female Chihuahua dog aged 2 months had a 3-week history of progressive neurological signs (abnormal behaviour, disorientation, left-sided circling, and incessant whimpering). Necropsy revealed a primary leiomyosarcoma in the midline of the posterior thalamus with secondary obstructive hydrocephalus of the lateral ventricles. Grossly, an infiltrative, grey-white tumour had partly invaded the third ventricle. Histologically, the tumour formed hypercellular, interlacing bundles of neoplastic spindle cells with blunt-ended nuclei. Neoplastic cells were strongly immunoreactive for vimentin and both muscle-specific and α-smooth muscle actin; MIB-1 immunoreactivity indicated a proliferative index of up to 5%. Leiomyosarcoma should be included in the differential diagnosis for primary brain tumours and hydrocephalus in young dogs.
Original language | English (US) |
---|---|
Pages (from-to) | 334-337 |
Number of pages | 4 |
Journal | Journal of Comparative Pathology |
Volume | 131 |
Issue number | 4 |
DOIs | |
State | Published - Nov 1 2004 |
Keywords
- Brain
- Dog
- Hydrocephalus
- Leiomyosarcoma
- Tumour
ASJC Scopus subject areas
- Pathology and Forensic Medicine
- veterinary(all)