Primary intra-axial leiomyosarcoma with obstructive hydrocephalus in a young dog

T. S. Zabka, J. A. Lavely, Robert Higgins

Research output: Contribution to journalArticlepeer-review

7 Scopus citations


A female Chihuahua dog aged 2 months had a 3-week history of progressive neurological signs (abnormal behaviour, disorientation, left-sided circling, and incessant whimpering). Necropsy revealed a primary leiomyosarcoma in the midline of the posterior thalamus with secondary obstructive hydrocephalus of the lateral ventricles. Grossly, an infiltrative, grey-white tumour had partly invaded the third ventricle. Histologically, the tumour formed hypercellular, interlacing bundles of neoplastic spindle cells with blunt-ended nuclei. Neoplastic cells were strongly immunoreactive for vimentin and both muscle-specific and α-smooth muscle actin; MIB-1 immunoreactivity indicated a proliferative index of up to 5%. Leiomyosarcoma should be included in the differential diagnosis for primary brain tumours and hydrocephalus in young dogs.

Original languageEnglish (US)
Pages (from-to)334-337
Number of pages4
JournalJournal of Comparative Pathology
Issue number4
StatePublished - Nov 1 2004


  • Brain
  • Dog
  • Hydrocephalus
  • Leiomyosarcoma
  • Tumour

ASJC Scopus subject areas

  • Pathology and Forensic Medicine
  • veterinary(all)


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