Primary biliary cirrhosis

Pietro Invernizzi, Patrick S Leung, Xiong Ma, M. Eric Gershwin

Research output: Chapter in Book/Report/Conference proceedingChapter

Abstract

PBC is a chronic cholestatic liver disease characterized by high-titer serum antimitochondrial autoantibodies (AMAs) and autoimmune-mediated destruction of small- and medium-sized intrahepatic bile ducts [1-3]. The first description of biliary cirrhosis, albeit possibly secondary, can be traced back to the work of the Italian pathologist Giovanni Battista Morgagni from Padua in 1761; the first report of nonobstructive biliary cirrhosis was by Addison and Gull in 1851. Subsequently, the term PBC was accepted in the medical literature [4], and in 1959 Dame Sheila Sherlock described the first series of patients affected by PBC who had been followed over the previous decade and noted that patients presented with pruritus as well as the signs and symptoms of end-stage liver disease including jaundice [5].

Original languageEnglish (US)
Title of host publicationLiver Immunology: Principles and Practice
PublisherSpringer International Publishing
Pages253-279
Number of pages27
ISBN (Print)9783319020969, 9783319020952
DOIs
StatePublished - Jan 1 2014

Fingerprint

Biliary Liver Cirrhosis
Charadriiformes
Intrahepatic Bile Ducts
End Stage Liver Disease
Return to Work
Pruritus
Jaundice
Autoantibodies
Signs and Symptoms
Liver Diseases
Serum
Pathologists

ASJC Scopus subject areas

  • Medicine(all)

Cite this

Invernizzi, P., Leung, P. S., Ma, X., & Gershwin, M. E. (2014). Primary biliary cirrhosis. In Liver Immunology: Principles and Practice (pp. 253-279). Springer International Publishing. https://doi.org/10.1007/978-3-319-02096-9_18

Primary biliary cirrhosis. / Invernizzi, Pietro; Leung, Patrick S; Ma, Xiong; Gershwin, M. Eric.

Liver Immunology: Principles and Practice. Springer International Publishing, 2014. p. 253-279.

Research output: Chapter in Book/Report/Conference proceedingChapter

Invernizzi, P, Leung, PS, Ma, X & Gershwin, ME 2014, Primary biliary cirrhosis. in Liver Immunology: Principles and Practice. Springer International Publishing, pp. 253-279. https://doi.org/10.1007/978-3-319-02096-9_18
Invernizzi P, Leung PS, Ma X, Gershwin ME. Primary biliary cirrhosis. In Liver Immunology: Principles and Practice. Springer International Publishing. 2014. p. 253-279 https://doi.org/10.1007/978-3-319-02096-9_18
Invernizzi, Pietro ; Leung, Patrick S ; Ma, Xiong ; Gershwin, M. Eric. / Primary biliary cirrhosis. Liver Immunology: Principles and Practice. Springer International Publishing, 2014. pp. 253-279
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