Primary and secondary zinc deficiency as factors contributing to abnormal central nervous system development

Carl L Keen, M. W. Taubeneck, G. P. Daston, M. Eric Gershwin, A. Ansari, J. M. Rogers

Research output: Contribution to journalArticle

10 Citations (Scopus)

Abstract

Zinc deficiency is a recognized reproductive hazard. The most common cause of embryonic zinc deficiency is low maternal plasma concentrations of the element, which can occur via numerous routes including the following: inadequate dietary zinc intake, genetic abnormalities in zinc metabolism, disease and drug-induced changes in zinc uptake and excretion, and cytokine-induced changes in zinc metabolism. Evidence is presented that tumor necrosis factor-α is a cytokine whose teratogenicity may be attributed, in part, to its effect on zinc metabolism. The concept that cytokine-induced changes in zinc metabolism represents a common mechanism underlying the developmental toxicity of several diverse toxicants is discussed.

Original languageEnglish (US)
Pages (from-to)79-89
Number of pages11
JournalDevelopmental Brain Dysfunction
Volume8
Issue number2-3
StatePublished - 1995

Fingerprint

Zinc
Central Nervous System
Cytokines
Tumor Necrosis Factor-alpha
Mothers
Pharmaceutical Preparations

Keywords

  • α-Hederin
  • Ethanol
  • Metallothionein
  • Pregnancy
  • Tumor necrosis factor-α
  • Urethane
  • Zinc

ASJC Scopus subject areas

  • Clinical Neurology
  • Neuroscience(all)

Cite this

Primary and secondary zinc deficiency as factors contributing to abnormal central nervous system development. / Keen, Carl L; Taubeneck, M. W.; Daston, G. P.; Gershwin, M. Eric; Ansari, A.; Rogers, J. M.

In: Developmental Brain Dysfunction, Vol. 8, No. 2-3, 1995, p. 79-89.

Research output: Contribution to journalArticle

Keen, Carl L ; Taubeneck, M. W. ; Daston, G. P. ; Gershwin, M. Eric ; Ansari, A. ; Rogers, J. M. / Primary and secondary zinc deficiency as factors contributing to abnormal central nervous system development. In: Developmental Brain Dysfunction. 1995 ; Vol. 8, No. 2-3. pp. 79-89.
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