Prevention of white-matter lesions through control of cerebrovascular risk factors

Research output: Contribution to journalArticlepeer-review

7 Scopus citations


Multiple epidemiological and brain imaging studies show a strong association between elevations in systolic blood pressure and lesions of cerebral white matter. The association between white-matter lesions and systolic blood pressure persists even if individuals are receiving treatment, suggesting that these individuals may be undertreated. In addition, these studies suggest that lesions of cerebral white matter may serve as markers for atherosclerotic vascular disease. Treatment strategies, therefore, should focus on early and aggressive management of elevated blood pressure, but definitions of elevated blood pressure may need to be revised downward to achieve best results.

Original languageEnglish (US)
Pages (from-to)147-151
Number of pages5
JournalInternational Psychogeriatrics
Issue numberSUPPL. 1
StatePublished - 2003


  • Atherosclerosis
  • Hypertension
  • Leukoaraiosis
  • Magnetic resonance imaging
  • Treatment
  • White-matter hyperintensities

ASJC Scopus subject areas

  • Geriatrics and Gerontology
  • Aging
  • Psychiatry and Mental health
  • Psychology(all)
  • Clinical Psychology


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