Abstract
Multiple epidemiological and brain imaging studies show a strong association between elevations in systolic blood pressure and lesions of cerebral white matter. The association between white-matter lesions and systolic blood pressure persists even if individuals are receiving treatment, suggesting that these individuals may be undertreated. In addition, these studies suggest that lesions of cerebral white matter may serve as markers for atherosclerotic vascular disease. Treatment strategies, therefore, should focus on early and aggressive management of elevated blood pressure, but definitions of elevated blood pressure may need to be revised downward to achieve best results.
| Original language | English (US) |
|---|---|
| Pages (from-to) | 147-151 |
| Number of pages | 5 |
| Journal | International Psychogeriatrics |
| Volume | 15 |
| Issue number | SUPPL. 1 |
| DOIs | |
| State | Published - 2003 |
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Keywords
- Atherosclerosis
- Hypertension
- Leukoaraiosis
- Magnetic resonance imaging
- Treatment
- White-matter hyperintensities
ASJC Scopus subject areas
- Geriatrics and Gerontology
- Aging
- Psychiatry and Mental health
- Psychology(all)
- Clinical Psychology
Cite this
Prevention of white-matter lesions through control of cerebrovascular risk factors. / DeCarli, Charles.
In: International Psychogeriatrics, Vol. 15, No. SUPPL. 1, 2003, p. 147-151.Research output: Contribution to journal › Article
}
TY - JOUR
T1 - Prevention of white-matter lesions through control of cerebrovascular risk factors
AU - DeCarli, Charles
PY - 2003
Y1 - 2003
N2 - Multiple epidemiological and brain imaging studies show a strong association between elevations in systolic blood pressure and lesions of cerebral white matter. The association between white-matter lesions and systolic blood pressure persists even if individuals are receiving treatment, suggesting that these individuals may be undertreated. In addition, these studies suggest that lesions of cerebral white matter may serve as markers for atherosclerotic vascular disease. Treatment strategies, therefore, should focus on early and aggressive management of elevated blood pressure, but definitions of elevated blood pressure may need to be revised downward to achieve best results.
AB - Multiple epidemiological and brain imaging studies show a strong association between elevations in systolic blood pressure and lesions of cerebral white matter. The association between white-matter lesions and systolic blood pressure persists even if individuals are receiving treatment, suggesting that these individuals may be undertreated. In addition, these studies suggest that lesions of cerebral white matter may serve as markers for atherosclerotic vascular disease. Treatment strategies, therefore, should focus on early and aggressive management of elevated blood pressure, but definitions of elevated blood pressure may need to be revised downward to achieve best results.
KW - Atherosclerosis
KW - Hypertension
KW - Leukoaraiosis
KW - Magnetic resonance imaging
KW - Treatment
KW - White-matter hyperintensities
UR - http://www.scopus.com/inward/record.url?scp=0141485221&partnerID=8YFLogxK
UR - http://www.scopus.com/inward/citedby.url?scp=0141485221&partnerID=8YFLogxK
U2 - 10.1017/S1041610203009116
DO - 10.1017/S1041610203009116
M3 - Article
C2 - 16191232
AN - SCOPUS:0141485221
VL - 15
SP - 147
EP - 151
JO - International Psychogeriatrics
JF - International Psychogeriatrics
SN - 1041-6102
IS - SUPPL. 1
ER -