Abstract
To the Editor: The study by Leyvraz et al. in the October 20 issue suggests that low-dose heparin adjusted according to activated partial thromboplastin time is more effective than the traditional fixed dose in prevention of deep-vein thrombosis after total hip replacement.1 Although this approach appears interesting, there are several flaws in the design and analysis of the study that should be pointed out. First of all, the control group was treated with 3500 IU of subcutaneous heparin every eight hours, which represents an unusual and probably substandard antithrombotic prophylaxis, since even a dosage of 5000 IU every eight hours.
| Original language | English (US) |
|---|---|
| Pages (from-to) | 927-928 |
| Number of pages | 2 |
| Journal | New England Journal of Medicine |
| Volume | 310 |
| Issue number | 14 |
| DOIs | |
| State | Published - Apr 5 1984 |
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ASJC Scopus subject areas
- Medicine(all)
Cite this
Prevention of Venous Thrombosis after Total Hip Replacement. / Pini, Mario; Carluccio, Luigi; Giovanardi, Claudio; Spadini, Elisabetta; White, Richard H; Hoaglund, Franklin T.; Bachmann, F.; Leyvraz, P. F.
In: New England Journal of Medicine, Vol. 310, No. 14, 05.04.1984, p. 927-928.Research output: Contribution to journal › Letter
}
TY - JOUR
T1 - Prevention of Venous Thrombosis after Total Hip Replacement
AU - Pini, Mario
AU - Carluccio, Luigi
AU - Giovanardi, Claudio
AU - Spadini, Elisabetta
AU - White, Richard H
AU - Hoaglund, Franklin T.
AU - Bachmann, F.
AU - Leyvraz, P. F.
PY - 1984/4/5
Y1 - 1984/4/5
N2 - To the Editor: The study by Leyvraz et al. in the October 20 issue suggests that low-dose heparin adjusted according to activated partial thromboplastin time is more effective than the traditional fixed dose in prevention of deep-vein thrombosis after total hip replacement.1 Although this approach appears interesting, there are several flaws in the design and analysis of the study that should be pointed out. First of all, the control group was treated with 3500 IU of subcutaneous heparin every eight hours, which represents an unusual and probably substandard antithrombotic prophylaxis, since even a dosage of 5000 IU every eight hours.
AB - To the Editor: The study by Leyvraz et al. in the October 20 issue suggests that low-dose heparin adjusted according to activated partial thromboplastin time is more effective than the traditional fixed dose in prevention of deep-vein thrombosis after total hip replacement.1 Although this approach appears interesting, there are several flaws in the design and analysis of the study that should be pointed out. First of all, the control group was treated with 3500 IU of subcutaneous heparin every eight hours, which represents an unusual and probably substandard antithrombotic prophylaxis, since even a dosage of 5000 IU every eight hours.
UR - http://www.scopus.com/inward/record.url?scp=0021351446&partnerID=8YFLogxK
UR - http://www.scopus.com/inward/citedby.url?scp=0021351446&partnerID=8YFLogxK
U2 - 10.1056/NEJM198404053101418
DO - 10.1056/NEJM198404053101418
M3 - Letter
C2 - 6700686
AN - SCOPUS:0021351446
VL - 310
SP - 927
EP - 928
JO - New England Journal of Medicine
JF - New England Journal of Medicine
SN - 0028-4793
IS - 14
ER -