Prevention of Venous Thrombosis after Total Hip Replacement

Mario Pini; Luigi Carluccio; Claudio Giovanardi; Elisabetta Spadini; Richard H White; Franklin T. Hoaglund; F. Bachmann; P. F. Leyvraz

doi:10.1056/NEJM198404053101418

Prevention of Venous Thrombosis after Total Hip Replacement

Mario Pini, Luigi Carluccio, Claudio Giovanardi, Elisabetta Spadini, Richard H White, Franklin T. Hoaglund, F. Bachmann, P. F. Leyvraz

General Medicine, Geriatrics, and Bioethics

Research output: Contribution to journal › Letter

Abstract

To the Editor: The study by Leyvraz et al. in the October 20 issue suggests that low-dose heparin adjusted according to activated partial thromboplastin time is more effective than the traditional fixed dose in prevention of deep-vein thrombosis after total hip replacement.¹ Although this approach appears interesting, there are several flaws in the design and analysis of the study that should be pointed out. First of all, the control group was treated with 3500 IU of subcutaneous heparin every eight hours, which represents an unusual and probably substandard antithrombotic prophylaxis, since even a dosage of 5000 IU every eight hours.

Original language	English (US)
Pages (from-to)	927-928
Number of pages	2
Journal	New England Journal of Medicine
Volume	310
Issue number	14
DOIs	https://doi.org/10.1056/NEJM198404053101418
State	Published - Apr 5 1984

ASJC Scopus subject areas

Medicine(all)

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10.1056/NEJM198404053101418

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Pini, M., Carluccio, L., Giovanardi, C., Spadini, E., White, R. H., Hoaglund, F. T., Bachmann, F., & Leyvraz, P. F. (1984). Prevention of Venous Thrombosis after Total Hip Replacement. New England Journal of Medicine, 310(14), 927-928. https://doi.org/10.1056/NEJM198404053101418

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AU - Pini, Mario

AU - Carluccio, Luigi

AU - Giovanardi, Claudio

AU - Spadini, Elisabetta

AU - White, Richard H

AU - Hoaglund, Franklin T.

AU - Bachmann, F.

AU - Leyvraz, P. F.

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N2 - To the Editor: The study by Leyvraz et al. in the October 20 issue suggests that low-dose heparin adjusted according to activated partial thromboplastin time is more effective than the traditional fixed dose in prevention of deep-vein thrombosis after total hip replacement.1 Although this approach appears interesting, there are several flaws in the design and analysis of the study that should be pointed out. First of all, the control group was treated with 3500 IU of subcutaneous heparin every eight hours, which represents an unusual and probably substandard antithrombotic prophylaxis, since even a dosage of 5000 IU every eight hours.

AB - To the Editor: The study by Leyvraz et al. in the October 20 issue suggests that low-dose heparin adjusted according to activated partial thromboplastin time is more effective than the traditional fixed dose in prevention of deep-vein thrombosis after total hip replacement.1 Although this approach appears interesting, there are several flaws in the design and analysis of the study that should be pointed out. First of all, the control group was treated with 3500 IU of subcutaneous heparin every eight hours, which represents an unusual and probably substandard antithrombotic prophylaxis, since even a dosage of 5000 IU every eight hours.

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