Prevention of Venous Thrombosis after Total Hip Replacement

Mario Pini, Luigi Carluccio, Claudio Giovanardi, Elisabetta Spadini, Richard H White, Franklin T. Hoaglund, F. Bachmann, P. F. Leyvraz

Research output: Contribution to journalLetter

Abstract

To the Editor: The study by Leyvraz et al. in the October 20 issue suggests that low-dose heparin adjusted according to activated partial thromboplastin time is more effective than the traditional fixed dose in prevention of deep-vein thrombosis after total hip replacement.1 Although this approach appears interesting, there are several flaws in the design and analysis of the study that should be pointed out. First of all, the control group was treated with 3500 IU of subcutaneous heparin every eight hours, which represents an unusual and probably substandard antithrombotic prophylaxis, since even a dosage of 5000 IU every eight hours.

Original languageEnglish (US)
Pages (from-to)927-928
Number of pages2
JournalNew England Journal of Medicine
Volume310
Issue number14
DOIs
StatePublished - Apr 5 1984

Fingerprint

Hip Replacement Arthroplasties
Venous Thrombosis
Heparin
Partial Thromboplastin Time
Hip
Control Groups

ASJC Scopus subject areas

  • Medicine(all)

Cite this

Pini, M., Carluccio, L., Giovanardi, C., Spadini, E., White, R. H., Hoaglund, F. T., ... Leyvraz, P. F. (1984). Prevention of Venous Thrombosis after Total Hip Replacement. New England Journal of Medicine, 310(14), 927-928. https://doi.org/10.1056/NEJM198404053101418

Prevention of Venous Thrombosis after Total Hip Replacement. / Pini, Mario; Carluccio, Luigi; Giovanardi, Claudio; Spadini, Elisabetta; White, Richard H; Hoaglund, Franklin T.; Bachmann, F.; Leyvraz, P. F.

In: New England Journal of Medicine, Vol. 310, No. 14, 05.04.1984, p. 927-928.

Research output: Contribution to journalLetter

Pini, M, Carluccio, L, Giovanardi, C, Spadini, E, White, RH, Hoaglund, FT, Bachmann, F & Leyvraz, PF 1984, 'Prevention of Venous Thrombosis after Total Hip Replacement', New England Journal of Medicine, vol. 310, no. 14, pp. 927-928. https://doi.org/10.1056/NEJM198404053101418
Pini M, Carluccio L, Giovanardi C, Spadini E, White RH, Hoaglund FT et al. Prevention of Venous Thrombosis after Total Hip Replacement. New England Journal of Medicine. 1984 Apr 5;310(14):927-928. https://doi.org/10.1056/NEJM198404053101418
Pini, Mario ; Carluccio, Luigi ; Giovanardi, Claudio ; Spadini, Elisabetta ; White, Richard H ; Hoaglund, Franklin T. ; Bachmann, F. ; Leyvraz, P. F. / Prevention of Venous Thrombosis after Total Hip Replacement. In: New England Journal of Medicine. 1984 ; Vol. 310, No. 14. pp. 927-928.
@article{df37f8d5df1c42f7901e1c7b9f33ca4c,
title = "Prevention of Venous Thrombosis after Total Hip Replacement",
abstract = "To the Editor: The study by Leyvraz et al. in the October 20 issue suggests that low-dose heparin adjusted according to activated partial thromboplastin time is more effective than the traditional fixed dose in prevention of deep-vein thrombosis after total hip replacement.1 Although this approach appears interesting, there are several flaws in the design and analysis of the study that should be pointed out. First of all, the control group was treated with 3500 IU of subcutaneous heparin every eight hours, which represents an unusual and probably substandard antithrombotic prophylaxis, since even a dosage of 5000 IU every eight hours.",
author = "Mario Pini and Luigi Carluccio and Claudio Giovanardi and Elisabetta Spadini and White, {Richard H} and Hoaglund, {Franklin T.} and F. Bachmann and Leyvraz, {P. F.}",
year = "1984",
month = "4",
day = "5",
doi = "10.1056/NEJM198404053101418",
language = "English (US)",
volume = "310",
pages = "927--928",
journal = "New England Journal of Medicine",
issn = "0028-4793",
publisher = "Massachussetts Medical Society",
number = "14",

}

TY - JOUR

T1 - Prevention of Venous Thrombosis after Total Hip Replacement

AU - Pini, Mario

AU - Carluccio, Luigi

AU - Giovanardi, Claudio

AU - Spadini, Elisabetta

AU - White, Richard H

AU - Hoaglund, Franklin T.

AU - Bachmann, F.

AU - Leyvraz, P. F.

PY - 1984/4/5

Y1 - 1984/4/5

N2 - To the Editor: The study by Leyvraz et al. in the October 20 issue suggests that low-dose heparin adjusted according to activated partial thromboplastin time is more effective than the traditional fixed dose in prevention of deep-vein thrombosis after total hip replacement.1 Although this approach appears interesting, there are several flaws in the design and analysis of the study that should be pointed out. First of all, the control group was treated with 3500 IU of subcutaneous heparin every eight hours, which represents an unusual and probably substandard antithrombotic prophylaxis, since even a dosage of 5000 IU every eight hours.

AB - To the Editor: The study by Leyvraz et al. in the October 20 issue suggests that low-dose heparin adjusted according to activated partial thromboplastin time is more effective than the traditional fixed dose in prevention of deep-vein thrombosis after total hip replacement.1 Although this approach appears interesting, there are several flaws in the design and analysis of the study that should be pointed out. First of all, the control group was treated with 3500 IU of subcutaneous heparin every eight hours, which represents an unusual and probably substandard antithrombotic prophylaxis, since even a dosage of 5000 IU every eight hours.

UR - http://www.scopus.com/inward/record.url?scp=0021351446&partnerID=8YFLogxK

UR - http://www.scopus.com/inward/citedby.url?scp=0021351446&partnerID=8YFLogxK

U2 - 10.1056/NEJM198404053101418

DO - 10.1056/NEJM198404053101418

M3 - Letter

C2 - 6700686

AN - SCOPUS:0021351446

VL - 310

SP - 927

EP - 928

JO - New England Journal of Medicine

JF - New England Journal of Medicine

SN - 0028-4793

IS - 14

ER -