Prevention of simian acquired immune deficiency syndrome with a formalin-inactivated type D retrovirus vaccine

P. A. Marx, N. C. Pedersen, N. W. Lerche, K. G. Osborn, L. J. Lowenstine, A. A. Lackner, D. H. Maul, H. S. Kwang, J. D. Kluge, C. P. Zaiss

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50 Scopus citations

Abstract

Experimental induction of simian acquired immune deficiency syndrome (SAIDS) by inoculation of juvenile rhesus monkeys with a type D retrovirus was prevented by immunization with Formalin-killed whole SAIDS retrovirus serotype 1 containing the adjuvant threonyl muramyl-dipeptide. All six immunized animals developed neutralizing antibody after three injections, while six aged-matched cagemates receiving adjuvant alone were antibody free. All 12 monkeys were challenged intravenously with a potentially lethal dose of SAIDS retrovirus serotype 1. The six immunized animals failed to develop persistent viremia and remained clinically normal 8 months postchallenge. In contrast, five of six nonvaccinates developed persistent viremia, four of six developed clinical SAIDS, and two of six died with SAIDS at 10 weeks and 8 months postchallenge, respectively. These results show that prevention of a common spontaneous retrovirus-induced immunosuppressive disease in macaques is now possible by vaccination.

Original languageEnglish (US)
Pages (from-to)431-435
Number of pages5
JournalJournal of Virology
Volume60
Issue number2
StatePublished - 1986

ASJC Scopus subject areas

  • Immunology

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    Marx, P. A., Pedersen, N. C., Lerche, N. W., Osborn, K. G., Lowenstine, L. J., Lackner, A. A., Maul, D. H., Kwang, H. S., Kluge, J. D., & Zaiss, C. P. (1986). Prevention of simian acquired immune deficiency syndrome with a formalin-inactivated type D retrovirus vaccine. Journal of Virology, 60(2), 431-435.