Prevention of simian acquired immune deficiency syndrome with a formalin-inactivated type D retrovirus vaccine

P. A. Marx, Niels C Pedersen, N. W. Lerche, K. G. Osborn, Linda J Lowenstine, A. A. Lackner, D. H. Maul, H. S. Kwang, J. D. Kluge, C. P. Zaiss

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Abstract

Experimental induction of simian acquired immune deficiency syndrome (SAIDS) by inoculation of juvenile rhesus monkeys with a type D retrovirus was prevented by immunization with Formalin-killed whole SAIDS retrovirus serotype 1 containing the adjuvant threonyl muramyl-dipeptide. All six immunized animals developed neutralizing antibody after three injections, while six aged-matched cagemates receiving adjuvant alone were antibody free. All 12 monkeys were challenged intravenously with a potentially lethal dose of SAIDS retrovirus serotype 1. The six immunized animals failed to develop persistent viremia and remained clinically normal 8 months postchallenge. In contrast, five of six nonvaccinates developed persistent viremia, four of six developed clinical SAIDS, and two of six died with SAIDS at 10 weeks and 8 months postchallenge, respectively. These results show that prevention of a common spontaneous retrovirus-induced immunosuppressive disease in macaques is now possible by vaccination.

Original languageEnglish (US)
Pages (from-to)431-435
Number of pages5
JournalJournal of Virology
Volume60
Issue number2
StatePublished - 1986

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Simian Acquired Immunodeficiency Syndrome
Betaretrovirus
acquired immunodeficiency syndrome
formalin
Retroviridae
Formaldehyde
Vaccines
vaccines
Viremia
viremia
adjuvants
serotypes
vaccination
Acetylmuramyl-Alanyl-Isoglutamine
immunosuppressive agents
dipeptides
lethal dose
Macaca
Immunosuppressive Agents
Macaca mulatta

ASJC Scopus subject areas

  • Immunology

Cite this

Prevention of simian acquired immune deficiency syndrome with a formalin-inactivated type D retrovirus vaccine. / Marx, P. A.; Pedersen, Niels C; Lerche, N. W.; Osborn, K. G.; Lowenstine, Linda J; Lackner, A. A.; Maul, D. H.; Kwang, H. S.; Kluge, J. D.; Zaiss, C. P.

In: Journal of Virology, Vol. 60, No. 2, 1986, p. 431-435.

Research output: Contribution to journalArticle

Marx, PA, Pedersen, NC, Lerche, NW, Osborn, KG, Lowenstine, LJ, Lackner, AA, Maul, DH, Kwang, HS, Kluge, JD & Zaiss, CP 1986, 'Prevention of simian acquired immune deficiency syndrome with a formalin-inactivated type D retrovirus vaccine', Journal of Virology, vol. 60, no. 2, pp. 431-435.
Marx, P. A. ; Pedersen, Niels C ; Lerche, N. W. ; Osborn, K. G. ; Lowenstine, Linda J ; Lackner, A. A. ; Maul, D. H. ; Kwang, H. S. ; Kluge, J. D. ; Zaiss, C. P. / Prevention of simian acquired immune deficiency syndrome with a formalin-inactivated type D retrovirus vaccine. In: Journal of Virology. 1986 ; Vol. 60, No. 2. pp. 431-435.
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