Abstract
Purpose In spite of four decades of research, necrotizing enterocolitis (NEC) remains the most common gastrointestinal complication in premature infants with high mortality and long-term morbidity. The composition of the intestinal microbiota of the premature infant differs dramatically from that of the healthy term infant and appears to be an important risk factor for NEC. Methods We review the evidence of an association between intestinal dysbiosis and NEC and summarize published English language clinical trials and cohort studies involving attempts to manipulate the intestinal microbiota in premature infants. Findings Promising NEC prevention strategies that alter the intestinal microbiota include probiotics, prebiotics, synbiotics, lacteroferrin, and human milk feeding. Implications Shaping the intestinal microbiota of the premature infant through human milk feeding and dietary supplements decreases the risk of NEC. Further studies to identify the ideal microbial composition and the most effective combination of supplements are indicated.
| Original language | English (US) |
|---|---|
| Pages (from-to) | 716-732 |
| Number of pages | 17 |
| Journal | Clinical Therapeutics |
| Volume | 38 |
| Issue number | 4 |
| DOIs | |
| State | Published - Apr 1 2016 |
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Keywords
- Key words s: human milk
- lactoferrin
- necrotizing enterocolitis
- prebiotic
- premature infant probiotic
- synbiotic
ASJC Scopus subject areas
- Pharmacology
- Pharmacology (medical)
Cite this
Prevention of Necrotizing Enterocolitis Through Manipulation of the Intestinal Microbiota of the Premature Infant. / Vongbhavit, Kannikar; Underwood, Mark.
In: Clinical Therapeutics, Vol. 38, No. 4, 01.04.2016, p. 716-732.Research output: Contribution to journal › Review article
}
TY - JOUR
T1 - Prevention of Necrotizing Enterocolitis Through Manipulation of the Intestinal Microbiota of the Premature Infant
AU - Vongbhavit, Kannikar
AU - Underwood, Mark
PY - 2016/4/1
Y1 - 2016/4/1
N2 - Purpose In spite of four decades of research, necrotizing enterocolitis (NEC) remains the most common gastrointestinal complication in premature infants with high mortality and long-term morbidity. The composition of the intestinal microbiota of the premature infant differs dramatically from that of the healthy term infant and appears to be an important risk factor for NEC. Methods We review the evidence of an association between intestinal dysbiosis and NEC and summarize published English language clinical trials and cohort studies involving attempts to manipulate the intestinal microbiota in premature infants. Findings Promising NEC prevention strategies that alter the intestinal microbiota include probiotics, prebiotics, synbiotics, lacteroferrin, and human milk feeding. Implications Shaping the intestinal microbiota of the premature infant through human milk feeding and dietary supplements decreases the risk of NEC. Further studies to identify the ideal microbial composition and the most effective combination of supplements are indicated.
AB - Purpose In spite of four decades of research, necrotizing enterocolitis (NEC) remains the most common gastrointestinal complication in premature infants with high mortality and long-term morbidity. The composition of the intestinal microbiota of the premature infant differs dramatically from that of the healthy term infant and appears to be an important risk factor for NEC. Methods We review the evidence of an association between intestinal dysbiosis and NEC and summarize published English language clinical trials and cohort studies involving attempts to manipulate the intestinal microbiota in premature infants. Findings Promising NEC prevention strategies that alter the intestinal microbiota include probiotics, prebiotics, synbiotics, lacteroferrin, and human milk feeding. Implications Shaping the intestinal microbiota of the premature infant through human milk feeding and dietary supplements decreases the risk of NEC. Further studies to identify the ideal microbial composition and the most effective combination of supplements are indicated.
KW - Key words s: human milk
KW - lactoferrin
KW - necrotizing enterocolitis
KW - prebiotic
KW - premature infant probiotic
KW - synbiotic
UR - http://www.scopus.com/inward/record.url?scp=84957927263&partnerID=8YFLogxK
UR - http://www.scopus.com/inward/citedby.url?scp=84957927263&partnerID=8YFLogxK
U2 - 10.1016/j.clinthera.2016.01.006
DO - 10.1016/j.clinthera.2016.01.006
M3 - Review article
VL - 38
SP - 716
EP - 732
JO - Clinical Therapeutics
JF - Clinical Therapeutics
SN - 0149-2918
IS - 4
ER -